Mocs1 Molybdenum cofactor synthesis 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mocs1provided by FlyBase
Official Full Name: Molybdenum cofactor synthesis 1provided by FlyBase
Primary source: FLYBASE:FBgn0263241
Locus tag: Dmel_CG33048
See related: AllianceGenome:FB:FBgn0263241
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG33048; CG7858; Dmel\CG33048; lxd; Mocs1A; MOCS1A; Mocs1A-B; Mocs1B; MOCS1B; mocsI; MocsI; MOCSI; Mosc1A+Mosc1B; pfs
Summary: Predicted to enable GTP 3',8'-cyclase activity and cyclic pyranopterin monophosphate synthase activity. Involved in inter-male aggressive behavior. Is expressed in several structures, including adult brain; embryonic/larval mushroom body; ganglia; imaginal disc; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type A. Orthologous to human MOCS1 (molybdenum cofactor synthesis 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 68A4-68A4; 3-34 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (11070526..11073348)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (11063626..11066448)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuronal-specific knockdown of pfs decreased aggressiveness. By contrast, overexpression of pfs greatly increased aggressiveness.
Title: The peacefulness gene promotes aggression in Drosophila.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables GTP 3',8'-cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTP 3',8'-cyclase activity	ISS Inferred from Sequence or Structural Similarity more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables cyclic pyranopterin monophosphate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclic pyranopterin monophosphate synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in Mo-molybdopterin cofactor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in Mo-molybdopterin cofactor biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in inter-male aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron-sulfur cluster assembly	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	TAS Traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: molybdenum cofactor synthesis 1

Names: CG33048-PA; CG33048-PC; Mocs1-PA; Mocs1-PC; low xanthine dehydrogenase; molybdenum cofactor synthesis 1 ortholog; peacefulness

NP_788494.1

EC 4.1.99.22

EC 4.6.1.17

NP_788495.1

EC 4.1.99.22

EC 4.6.1.17

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

11070526..11073348

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_176316.2 → NP_788494.1 molybdenum cofactor synthesis 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788494.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IQF1, Q9NIG3, Q9NIG4, Q9VTE4

Related

FBpp0075935

Conserved Domains (4) summary

cd01335
Location:74 → 249

Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...

PRK00164
Location:59 → 366

moaA; molybdenum cofactor biosynthesis protein A; Reviewed

PRK09364
Location:399 → 555

moaC; molybdenum cofactor biosynthesis protein MoaC; Provisional

pfam06463
Location:240 → 367

Mob_synth_C; Molybdenum Cofactor Synthesis C
NM_176317.2 → NP_788495.1 molybdenum cofactor synthesis 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788495.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IQF1

Related

FBpp0075934

Conserved Domains (3) summary

cd01335
Location:74 → 249

Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...

PLN02951
Location:43 → 385

PLN02951; Molybderin biosynthesis protein CNX2

pfam06463
Location:240 → 367

Mob_synth_C; Molybdenum Cofactor Synthesis C