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    CG11251 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39490, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11251provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036346
    Locus tag
    Dmel_CG11251
    See related
    AllianceGenome:FB:FBgn0036346
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG11251
    Summary
    Predicted to enable acetylpyruvate hydrolase activity. Orthologous to human FAHD2A (fumarylacetoacetate hydrolase domain containing 2A) and FAHD2B (fumarylacetoacetate hydrolase domain containing 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11251 in Genome Data Viewer
    Location:
    70A1-70A1; 3-40 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13088581..13089969, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13081681..13083069, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43652 Neighboring gene long non-coding RNA:CR45749 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44554 Neighboring gene tartan

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. tartan underlies the evolution of Drosophila male genital morphology. Hagen JFD, et al. Proc Natl Acad Sci U S A, 2019 Sep 17. PMID 31484761, Free PMC Article
    2. A genome-wide RNAi screen reveals multiple regulators of caspase activation. Yi CH, et al. J Cell Biol, 2007 Nov 19. PMID 17998402, Free PMC Article
    3. Unraveling the Genetic Basis for the Rapid Diversification of Male Genitalia between Drosophila Species. Hagen JFD, et al. Mol Biol Evol, 2021 Jan 23. PMID 32931587, Free PMC Article
    4. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article
    5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetylpyruvate hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11251-PA
    NP_648632.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13088581..13089969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140375.3 → NP_648632.1  uncharacterized protein Dmel_CG11251 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648632.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU50
      Related
      FBpp0075625
      Conserved Domains (2) summary
      TIGR02303
      Location:112 → 334
      HpaG-C-term; 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit
      pfam01557
      Location:135 → 333
      FAA_hydrolase; Fumarylacetoacetate (FAA) hydrolase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VU50 Q9VU50

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