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    CG4613 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39586, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4613provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036427
    Locus tag
    Dmel_CG4613
    See related
    AllianceGenome:FB:FBgn0036427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4613; SP40
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4613 in Genome Data Viewer
    Location:
    70E1-70E1; 3-42 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14519760..14521690, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14512860..14514790, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46031 Neighboring gene big bang Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mitochondrial phosphate carrier protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defensive repertoire of Drosophila larvae in response to toxic fungi. Trienens M, et al. Mol Ecol, 2017 Oct. PMID 28746736
    2. Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. Nakano S, et al. PLoS Genet, 2023 Jun. PMID 37319131, Free PMC Article
    3. Comparative exploration of mammalian deafness gene homologues in the Drosophila auditory organ shows genetic correlation between insect and vertebrate hearing. Sutton DC, et al. PLoS One, 2024. PMID 38412189, Free PMC Article
    4. Enhanced function annotations for Drosophila serine proteases: a case study for systematic annotation of multi-member gene families. Shah PK, et al. Gene, 2008 Jan 15. PMID 17996400
    5. Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Ross J, et al. Gene, 2003 Jan 30. PMID 12568721

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4613-PB
    CG4613-PC
    NP_001261841.1
    NP_648707.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14519760..14521690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274912.1 → NP_001261841.1  uncharacterized protein Dmel_CG4613, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261841.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUF0
      Conserved Domains (2) summary
      smart00020
      Location:136 → 362
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:137 → 362
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_140450.2 → NP_648707.2  uncharacterized protein Dmel_CG4613, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648707.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUF0
      Conserved Domains (2) summary
      smart00020
      Location:136 → 362
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:137 → 362
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUF0 Q9VUF0

    Gene LinkOut

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