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    MED27 Mediator complex subunit 27 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40696, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MED27provided by FlyBase
    Official Full Name
    Mediator complex subunit 27provided by FlyBase
    Primary source
    FLYBASE:FBgn0037359
    Locus tag
    Dmel_CG1245
    See related
    AllianceGenome:FB:FBgn0037359
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1245; CRSP34; dCrsp34; dCRSP34; Dmel\CG1245; dTRAP37; med27; Med27; Trap37
    Summary
    Predicted to enable transcription coactivator activity. Predicted to contribute to transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Part of mediator complex. Is expressed in several structures, including central brain primordium; ganglia; larval nervous system; and ventral nerve cord primordium. Orthologous to human MED27 (mediator complex subunit 27). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MED27 in Genome Data Viewer
    Location:
    83B8-83B8; 3-47.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5655139..5656336)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1480861..1482058)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Secretory 23 Neighboring gene ethanol sensitive with low memory Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44093 Neighboring gene WD repeat domain 33 Neighboring gene antisense RNA:CR46134

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Imp and Syp mediated temporal patterning of neural stem cells in the developing Drosophila CNS. Islam IM, et al. Genetics, 2022 Aug 30. PMID 35881070, Free PMC Article
    2. Imp and Syp RNA-binding proteins govern decommissioning of Drosophila neural stem cells. Yang CP, et al. Development, 2017 Oct 1. PMID 28851709, Free PMC Article
    3. Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity. Park J, et al. Elife, 2019 Jun 21. PMID 31223115, Free PMC Article
    4. Eye transformer is a negative regulator of Drosophila JAK/STAT signaling. Kallio J, et al. FASEB J, 2010 Nov. PMID 20624926
    5. Transcription regulation and animal diversity. Levine M, et al. Nature, 2003 Jul 10. PMID 12853946

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to transcription coregulator activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator complex subunit 27
    Names
    CG1245-PA
    MED27-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5655139..5656336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141312.4 → NP_649569.1  mediator complex subunit 27 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649569.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VNG0
      Related
      FBpp0078361
      Conserved Domains (1) summary
      pfam11571
      Location:209 → 287
      Med27; Mediator complex subunit 27
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNG0.1 Q9VNG0

    Gene LinkOut

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