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    Whamy WHAMM and JMY related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41198, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Whamyprovided by FlyBase
    Official Full Name
    WHAMM and JMY relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037750
    Locus tag
    Dmel_CG12946
    See related
    AllianceGenome:FB:FBgn0037750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12946; Dmel\CG12946; whamy
    Summary
    Enables small GTPase binding activity. Involved in several processes, including microtubule bundle formation; myoblast fusion; and positive regulation of supramolecular fiber organization. Located in lamellipodium; nucleus; and recycling endosome. Colocalizes with mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Whamy in Genome Data Viewer
    Location:
    85E8-85E8; 3-49 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9771795..9774419, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5597517..5600141, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Mediator complex subunit 6 Neighboring gene N(alpha)-acetyltransferase 80 Neighboring gene uncharacterized protein Neighboring gene matotopetli Neighboring gene ncRNA Neighboring gene Ribosomal protein S29

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental expression of Drosophila Wiskott-Aldrich Syndrome family proteins. Rodriguez-Mesa E, et al. Dev Dyn, 2012 Mar. PMID 22275148, Free PMC Article
    2. Wiskott-Aldrich syndrome proteins in the nucleus: aWASH with possibilities. Verboon JM, et al. Nucleus, 2015. PMID 26305109, Free PMC Article
    3. WHAMY is a novel actin polymerase promoting myoblast fusion, macrophage cell motility and sensory organ development in Drosophila. Brinkmann K, et al. J Cell Sci, 2016 Feb 1. PMID 26675239
    4. Arp2/3-mediated F-actin formation controls regulated exocytosis in vivo. Tran DT, et al. Nat Commun, 2015 Dec 7. PMID 26639106, Free PMC Article
    5. Swip-1 promotes exocytosis of glue granules in the exocrine Drosophila salivary gland. Lehne F, et al. J Cell Sci, 2023 Mar 15. PMID 36727484, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Wash, WASp, SCAR, and Whamy are dynamically expressed throughout oogenesis and embryogenesis.
      Title: Developmental expression of Drosophila Wiskott-Aldrich Syndrome family proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule bundle formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in myoblast fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WHAMM and JMY related
    Names
    CG12946-PA
    CG12946-PB
    CG12946-PC
    CG12946-PD
    CG12946-PE
    Whamy-PA
    Whamy-PB
    Whamy-PC
    Whamy-PD
    Whamy-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9771795..9774419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275506.1 → NP_001262435.1  WHAMM and JMY related, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYK0, Q9VH71
      Conserved Domains (1) summary
      pfam02205
      Location:442 → 464
      WH2; WH2 motif

    2. NM_001275507.1 → NP_001262436.1  WHAMM and JMY related, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262436.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH08, Q8SYK0
      Conserved Domains (1) summary
      pfam02205
      Location:524 → 546
      WH2; WH2 motif

    3. NM_001043234.2 → NP_001036699.1  WHAMM and JMY related, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036699.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI93, Q8SYK0
      Conserved Domains (1) summary
      pfam02205
      Location:558 → 580
      WH2; WH2 motif

    4. NM_141687.1 → NP_649944.1  WHAMM and JMY related, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649944.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYK0, Q9VH71
      Related
      FBpp0081637, FBtr0082159
      Conserved Domains (1) summary
      pfam02205
      Location:442 → 464
      WH2; WH2 motif

    5. NM_001275508.1 → NP_001262437.1  WHAMM and JMY related, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262437.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH08, Q8SYK0
      Conserved Domains (1) summary
      pfam02205
      Location:524 → 546
      WH2; WH2 motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KH08 A0A0B4KH08
    Q0KI93 Q0KI93
    Q8SYK0 Q8SYK0
    Q9VH71 Q9VH71

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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