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    Ugt35C1 UDP-glycosyltransferase family 35 member C1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53507, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ugt35C1provided by FlyBase
    Official Full Name
    UDP-glycosyltransferase family 35 member C1provided by FlyBase
    Primary source
    FLYBASE:FBgn0040256
    Locus tag
    Dmel_CG6633
    See related
    AllianceGenome:FB:FBgn0040256
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AC 006491D; CG6633; Dmel\CG6633; UGT35C1; Ugt86Dd
    Summary
    Predicted to enable UDP-glycosyltransferase activity. Predicted to be involved in glycosylation. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A3 (UDP glucuronosyltransferase family 1 member A3); UGT1A4 (UDP glucuronosyltransferase family 1 member A4); and UGT1A8 (UDP glucuronosyltransferase family 1 member A8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ugt35C1 in Genome Data Viewer
    Location:
    86D4-86D4; 3-50 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11126597..11128328, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6952319..6954050, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45579 Neighboring gene Succinate dehydrogenase, subunit C-like Neighboring gene Mitochondrial aconitase 2 Neighboring gene Chemosensory protein A 86a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A naturally-occurring 22-bp coding deletion in Ugt86Dd reduces nicotine resistance in Drosophila melanogaster. Macdonald SJ, et al. BMC Res Notes, 2020 Mar 30. PMID 32228671, Free PMC Article
    2. Naturally Segregating Variation at Ugt86Dd Contributes to Nicotine Resistance in Drosophila melanogaster. Highfill CA, et al. Genetics, 2017 Sep. PMID 28743761, Free PMC Article
    3. Behavioural Effects and RNA-seq Analysis of Aβ42-Mediated Toxicity in a Drosophila Alzheimer's Disease Model. Tan FHP, et al. Mol Neurobiol, 2023 Aug. PMID 37145377
    4. Identification of methylmercury tolerance gene candidates in Drosophila. Mahapatra CT, et al. Toxicol Sci, 2010 Jul. PMID 20375079, Free PMC Article
    5. Revisiting the protein-coding gene catalog of Drosophila melanogaster using 12 fly genomes. Lin MF, et al. Genome Res, 2007 Dec. PMID 17989253, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables UDP-glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glycosyltransferase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycosylation ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-glycosyltransferase family 35 member C1
    Names
    CG6633-PB
    UDP-glycosyltransferase 86Dd
    Ugt35C1-PB
    Ugt86Dd
    NP_001097744.1
    • frameshift, may be evolving pseudogene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11126597..11128328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104274.2 → NP_001097744.1  UDP-glycosyltransferase family 35 member C1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097744.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V3X8, Q9VGT8
      Conserved Domains (1) summary
      PHA03392
      Location:1 → 470
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGT8 Q9VGT8

    Gene LinkOut

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