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    Mrp4 Multidrug resistance protein 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41387, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrp4provided by FlyBase
    Official Full Name
    Multidrug resistance protein 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0263316
    Locus tag
    Dmel_CG14709
    See related
    AllianceGenome:FB:FBgn0263316
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:CK01227; BEST:CK02472; CG14709; CK01227; DmCG14709; Dmel\CG14709; Dme_CG14709; dMrp4; dMRP4; EP3221; MRP4
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in several processes, including determination of adult lifespan; response to anoxia; and wing disc dorsal/ventral pattern formation. Predicted to be active in membrane. Is expressed in adult head; eye disc; larval central nervous system; larval ventral nerve cord; and photoreceptor neurons. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mrp4 in Genome Data Viewer
    Location:
    86E11-86E11; 3-51 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11569250..11575937)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7394972..7401659)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fatty acid binding protein Neighboring gene scheggia Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene whacked

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila dMRP4 regulates responsiveness to O2 deprivation and development under hypoxia. Huang H, et al. Physiol Genomics, 2007 May 11. PMID 17284667
    2. Overexpression of SIRT3 Suppresses Oxidative Stress-induced Neurotoxicity and Mitochondrial Dysfunction in Dopaminergic Neuronal Cells. Lee S, et al. Exp Neurobiol, 2021 Oct 31. PMID 34737239, Free PMC Article
    3. Drosophila embryonic 'fibroblasts': extending mutant analysis in vitro. Simcox AA, et al. Fly (Austin), 2008 Nov-Dec. PMID 19077546, Free PMC Article
    4. Modulation of oxidative stress resistance in Drosophila melanogaster by gene overexpression. Monnier V, et al. Genesis, 2002 Sep-Oct. PMID 12324953
    5. Genetic analysis of hypoxia tolerance and susceptibility in Drosophila and humans. Zhou D, et al. Annu Rev Genomics Hum Genet, 2013. PMID 23808366

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to anoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wing disc dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    multidrug resistance protein 4
    Names
    CG14709-PB
    EP3221
    Mrp4-PB
    multidrug resistance protein 4 ortholog
    NP_650086.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11569250..11575937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141829.3 → NP_650086.2  multidrug resistance protein 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650086.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E786, Q9VGM1
      Conserved Domains (4) summary
      cd03244
      Location:1051 → 1272
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:422 → 622
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:12 → 1277
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:735 → 978
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGM1 Q9VGM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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