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    CG5245 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41530, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5245provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038047
    Locus tag
    Dmel_CG5245
    See related
    AllianceGenome:FB:FBgn0038047
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.611; Dmel\CG5245
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. Orthologous to several human genes including ZNF254 (zinc finger protein 254); ZNF571 (zinc finger protein 571); and ZNF595 (zinc finger protein 595). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5245 in Genome Data Viewer
    Location:
    87B10-87B10; 3-52 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12429560..12431235)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8255282..8256957)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Protein phosphatase 1 at 87B Neighboring gene N-acetylneuraminic acid synthase Neighboring gene uncharacterized protein Neighboring gene Proteasome alpha2 subunit Neighboring gene Activator of SUMO 1 Neighboring gene Spliceosome-ribosome linker protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic suppressor of two dominant temperature-sensitive lethal proteasome mutants of Drosophila melanogaster is itself a mutated proteasome subunit gene. Neuburger PJ, et al. Genetics, 2006 Jul. PMID 16648584, Free PMC Article
    2. Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes. Stevaux O, et al. Cell Cycle, 2005 Sep. PMID 16082225
    3. Functional variants identify sex-specific genes and pathways in Alzheimer's Disease. Bourquard T, et al. Nat Commun, 2023 May 13. PMID 37179358, Free PMC Article
    4. A network model of the molecular organization of chromatin in Drosophila. van Bemmel JG, et al. Mol Cell, 2013 Feb 21. PMID 23438860
    5. Age-dependent chromosomal distribution of male-biased genes in Drosophila. Zhang YE, et al. Genome Res, 2010 Nov. PMID 20798392, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5245-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12429560..12431235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141940.3 → NP_650197.1  uncharacterized protein Dmel_CG5245 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650197.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VG72
      Related
      FBpp0082061
      Conserved Domains (3) summary
      COG5048
      Location:74 → 478
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:179 → 204
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VG72 Q9VG72

    Gene LinkOut

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