kay kayak [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: kayprovided by FlyBase
Official Full Name: kayakprovided by FlyBase
Primary source: FLYBASE:FBgn0001297
Locus tag: Dmel_CG33956
See related: AllianceGenome:FB:FBgn0001297
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AP-1; Ap1; AP1; c-fos; c-Fos; CG15507; CG15509; CG33956; d-fos; d-Fos; D-fos; D-Fos; D-fos/kay; dAP-1; dfos; dFos; Dfos; DFos; DFOS; dFra; dFRA; DFra; dlhD; DM3; DM30; Dmel\CG33956; fbz; fos; Fos; FOS; fra; Fra; Kay; KAY
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including imaginal disc fusion, thorax closure; locomotor rhythm; and nervous system development. Acts upstream of with a positive effect on G2/M transition of mitotic cell cycle and second mitotic wave involved in compound eye morphogenesis. Located in cytoplasm and nucleus. Part of transcription factor AP-1 complex. Is expressed in several structures, including epithelial cell; epithelium; gut section; motor neurons; and sensory neurons. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human FOSL1 (FOS like 1, AP-1 transcription factor subunit); FOSL2 (FOS like 2, AP-1 transcription factor subunit); and FOS (Fos proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 99B10-99C1; 3-99 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29765995..29794113)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25591717..25619835)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cell polarity disruption activates JNK signaling, which in turn upregulate Wingless expression through transcription factor activator protein-1
Title: Wingless modulates activator protein-1-mediated tumor invasion.
c-Fos/CREB cycling defines long-term memories (LTM) engram cells required for LTM.
Title: Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling.
In wild-type ovarian cells, c-Fos is post-transcriptionally repressed by Piwi, which destabilized the c-Fos mRNA by promoting the processing of its 3' untranslated region (UTR) into Piwi-interacting RNAs (piRNAs).
Title: c-Fos Repression by Piwi Regulates Drosophila Ovarian Germline Formation and Tissue Morphogenesis.
malignant transformation of the ras(V12)scrib(1) tumors requires bZIP protein Fos, the ETS-domain factor Ets21c and the nuclear receptor Ftz-F1, all acting downstream of Jun-N-terminal kinase.
Title: Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy.
AP-1-dependent gene transcription is upregulated by increased neural activity during development.
Title: Temporal coherency between receptor expression, neural activity and AP-1-dependent transcription regulates Drosophila motoneuron dendrite development.
Ebi/AP-1 suppresses basal transcription levels of apoptotic genes and thereby protects sensory neurons from degeneration
Title: Ebi/AP-1 suppresses pro-apoptotic genes expression and permits long-term survival of Drosophila sensory neurons.
Clathrin and AP-1 colocalize at the trans-Golgi network; clathrin and AP-1 colocalize with secretory cargo at the TGN and on immature granules; loss of clathrin or AP-1 leads to a profound block in secretory granule formation.
Title: AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila.
It was shown that the AP-1 complex causes apical accumulation of the Notch activator Sanpodo and stabilization of both Sanpodo and Notch at the interface between sense organ precursor daughter cells.
Title: AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursors.
AP-1 mediated synapse enhancement and its relationship to increases in synapse number, Ca2+ influx, Ca2+ sensitivity of vesicle fusion or synaptic vesicle number, were examined.
Title: Fos and Jun potentiate individual release sites and mobilize the reserve synaptic vesicle pool at the Drosophila larval motor synapse.
expression of Fos bZip elicits male-specific phenotypes.
Title: A male-specific effect of dominant-negative Fos.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R3/R4 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collateral sprouting of injured axon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc fusion, thorax closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	HMP more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	HMP more info	PubMed
involved_in positive regulation of border follicle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect second mitotic wave involved in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor AP-1 complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: kayak

Names: CG33956-PA; CG33956-PB; CG33956-PD; CG33956-PF; CG33956-PG; Dfos/kayak; Fos; Fos-related antigen; activator protein 1; dorsal holes D; kay-PA; kay-PB; kay-PD; kay-PF; kay-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

29765995..29794113

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001032408.3 → NP_001027580.1 kayak, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027580.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8MPH8, A8MPH9

Conserved Domains (1) summary

cd14721
Location:387 → 448

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
NM_001300662.1 → NP_001287591.1 kayak, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287591.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LHU8

Conserved Domains (1) summary

cd14721
Location:311 → 372

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
NM_001032407.3 → NP_001027579.1 kayak, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027579.1

Status: REVIEWED

UniProtKB/TrEMBL

C4JC86

Conserved Domains (1) summary

cd14721
Location:260 → 321

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
NM_001032406.2 → NP_001027578.1 kayak, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027578.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P21525

Conserved Domains (1) summary

cd14721
Location:211 → 272

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
NM_001032405.4 → NP_001027577.2 kayak, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027577.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A8MPI0, P21525, Q400M6, Q400M7, Q53YJ8, Q8T9E2, Q9BH37, Q9NBW7, Q9VAH5

Conserved Domains (1) summary

cd14721
Location:420 → 481

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain