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    Ir100a Ionotropic receptor 100a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43753, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ir100aprovided by FlyBase
    Official Full Name
    Ionotropic receptor 100aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039879
    Locus tag
    Dmel_CG11575
    See related
    AllianceGenome:FB:FBgn0039879
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    100a; CG11575; DmelIR100a; Dmel\CG11575; IR100a
    Summary
    Predicted to enable ligand-gated monoatomic ion channel activity. Involved in sensory perception of taste. Predicted to be located in membrane. Is expressed in dorsal cibarial sense organ neurons; labral sense organ neurons; larval gustatory receptor neuron of the dorsal pharyngeal sense organ; larval gustatory receptor neuron of the posterior pharyngeal sense organ; and posterior pharyngeal sense organ. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ir100a in Genome Data Viewer
    Location:
    100D2-100D2; 3-102 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31800963..31802774)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27626685..27628496)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene fat facets Neighboring gene Methylcrotonoyl-CoA carboxylase 1 Neighboring gene ATP-dependent chromatin assembly factor large subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Riboflavin transporter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combinatorial Pharyngeal Taste Coding for Feeding Avoidance in Adult Drosophila. Chen YD, et al. Cell Rep, 2019 Oct 22. PMID 31644916, Free PMC Article
    2. Peripheral Sensory Organs Contribute to Temperature Synchronization of the Circadian Clock in Drosophila melanogaster. George R, et al. Front Physiol, 2021. PMID 33603678, Free PMC Article
    3. A single pair of pharyngeal neurons functions as a commander to reject high salt in Drosophila melanogaster. Sang J, et al. Elife, 2024 Apr 4. PMID 38573740, Free PMC Article
    4. The multidimensional ionotropic receptors of Drosophila melanogaster. Rimal S, et al. Insect Mol Biol, 2018 Feb. PMID 28857341
    5. Avoiding cantharidin through ionotropic receptors. Pradhan RN, et al. J Hazard Mater, 2024 Mar 15. PMID 38278077

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated monoatomic ion channel activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detection of chemical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in sensory perception of taste IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ionotropic receptor 100a
    Names
    CG11575-PA
    Ir100a-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31800963..31802774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143641.1 → NP_651898.2  ionotropic receptor 100a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651898.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9T2
      Related
      FBpp0085205, FBtr0085846
      Conserved Domains (2) summary
      pfam00060
      Location:439 → 580
      Lig_chan; Ligand-gated ion channel
      cl21456
      Location:210 → 255
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V9T2 Q9V9T2

    Gene LinkOut

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