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    4E-T eIF4E-Transporter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    4E-Tprovided by FlyBase
    Official Full Name
    eIF4E-Transporterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052016
    Locus tag
    Dmel_CG32016
    See related
    AllianceGenome:FB:FBgn0052016
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11097; CG11232; CG32016; Dm4E-T; Dmel\CG32016
    Summary
    Enables eukaryotic initiation factor 4E binding activity. Involved in negative regulation of eukaryotic translation initiation factor 4F complex assembly. Located in P-body; cytosol; and nucleus. Is expressed in adult head. Orthologous to human EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See 4E-T in Genome Data Viewer
    Location:
    102F3-102F3; 4-0 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (951542..958392, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (972168..979018, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4G1 Neighboring gene metabotropic Glutamate Receptor Neighboring gene long non-coding RNA:CR45201 Neighboring gene antisense RNA:CR44030 Neighboring gene fussel

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing. Kamenska A, et al. Nucleic Acids Res, 2014 Mar. PMID 24335285, Free PMC Article
    2. Adult Movement Defects Associated with a CORL Mutation in Drosophila Display Behavioral Plasticity. Dimitriadou A, et al. G3 (Bethesda), 2020 May 4. PMID 32161085, Free PMC Article
    3. 4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation. Igreja C, et al. Nat Commun, 2014 Sep 2. PMID 25179781, Free PMC Article
    4. Molecular architecture of 4E-BP translational inhibitors bound to eIF4E. Peter D, et al. Mol Cell, 2015 Mar 19. PMID 25702871
    5. CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila. Tran NL, et al. G3 (Bethesda), 2018 Aug 30. PMID 30006413, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c953198-953151 mobile_element_type = transposon:1360{}3507
    • Loc: c956342-955139 mobile_element_type = transposon:INE-1{}2903

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables eukaryotic initiation factor 4E binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of eukaryotic translation initiation factor 4F complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eIF4E-Transporter
    Names
    4E-T-PB
    4E-T-PC
    4E-T-PG
    4E-T-PH
    CG32016-PB
    CG32016-PC
    CG32016-PG
    CG32016-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      951542..958392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166797.2 → NP_726619.2  eIF4E-Transporter, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726619.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      L0MLQ9, Q86BR2, Q8IH18, Q8IMA1
      UniProtKB/TrEMBL
      E8NH84
      Related
      FBpp0088293
      Conserved Domains (1) summary
      pfam10477
      Location:10 → 736
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    2. NM_166796.2 → NP_726618.3  eIF4E-Transporter, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726618.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      L0MLQ9, Q86BR2, Q8IH18, Q8IMA1
      UniProtKB/TrEMBL
      E8NH84
      Conserved Domains (1) summary
      pfam10477
      Location:10 → 736
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    3. NM_166798.2 → NP_726620.2  eIF4E-Transporter, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726620.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      L0MLQ9, Q86BR2, Q8IH18, Q8IMA1
      UniProtKB/TrEMBL
      E8NH84
      Related
      FBpp0088297
      Conserved Domains (1) summary
      pfam10477
      Location:10 → 736
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    4. NM_001272149.2 → NP_001259078.1  eIF4E-Transporter, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259078.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH84
      Conserved Domains (1) summary
      pfam10477
      Location:10 → 705
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IH18.1 Q8IH18

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