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    GramD1B GRAM domain containing 1B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33552, updated on 4-Jan-2025

    Summary

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    Official Symbol
    GramD1Bprovided by FlyBase
    Official Full Name
    GRAM domain containing 1Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085423
    Locus tag
    Dmel_CG34394
    See related
    AllianceGenome:FB:FBgn0085423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE58243; CG15411; CG3304; CG34394; Dmel\CG34394
    Old locus tag
    CG15411; CG3304; Dmel_CG15411; Dmel_CG3304
    Summary
    Predicted to enable sterol binding activity and sterol transfer activity. Predicted to be involved in intracellular sterol transport. Predicted to be active in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Is expressed in adult head; embryonic/larval Malpighian tubule; embryonic/larval gut; and larval brain. Orthologous to several human genes including GRAMD1C (GRAM domain containing 1C). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See GramD1B in Genome Data Viewer
    Location:
    23E5-23F1; 2-9 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3358640..3373372, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3358640..3373372, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Early gene at 23 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GRAM domain-containing protein 1B (GRAMD1B), a novel component of the JAK/STAT signaling pathway, functions in gastric carcinogenesis. Khanna P, et al. Oncotarget, 2017 Dec 29. PMID 29383166, Free PMC Article
    2. Deep sequencing of the prothoracic gland transcriptome reveals new players in insect ecdysteroidogenesis. Nakaoka T, et al. PLoS One, 2017. PMID 28257485, Free PMC Article
    3. Comparative transcriptional profiling and evolutionary analysis of the GRAM domain family in eukaryotes. Jiang SY, et al. Dev Biol, 2008 Feb 15. PMID 18201690
    4. Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of Drosophila. Hazelett DJ, et al. G3 (Bethesda), 2012 Jul. PMID 22870402, Free PMC Article
    5. Genome features of "Dark-fly", a Drosophila line reared long-term in a dark environment. Izutsu M, et al. PLoS One, 2012. PMID 22432011, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sterol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular sterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-plasma membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GRAM domain containing 1B
    Names
    CG34394-PA
    CG34394-PC
    CG34394-PD
    CG34394-PE
    CG34394-PG
    CG34394-PH
    GramD1B-PA
    GramD1B-PC
    GramD1B-PD
    GramD1B-PE
    GramD1B-PG
    GramD1B-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3358640..3373372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134926.4 → NP_608770.4  GRAM domain containing 1B, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      R9PY34
      Conserved Domains (2) summary
      cd13220
      Location:324 → 417
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:717 → 863
      DUF4782; Domain of unknown function (DUF4782)

    2. NM_001103598.3 → NP_001097068.1  GRAM domain containing 1B, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYU1
      Conserved Domains (2) summary
      cd13220
      Location:422 → 515
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:815 → 961
      DUF4782; Domain of unknown function (DUF4782)

    3. NM_205901.3 → NP_995623.2  GRAM domain containing 1B, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      R9PY62
      Conserved Domains (2) summary
      cd13220
      Location:358 → 451
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:751 → 897
      DUF4782; Domain of unknown function (DUF4782)

    4. NM_001103599.3 → NP_001097069.1  GRAM domain containing 1B, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYU2
      Conserved Domains (2) summary
      cd13220
      Location:348 → 441
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:741 → 887
      DUF4782; Domain of unknown function (DUF4782)

    5. NM_001103601.3 → NP_001097071.1  GRAM domain containing 1B, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYU3
      Conserved Domains (2) summary
      cd13220
      Location:348 → 441
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:741 → 887
      DUF4782; Domain of unknown function (DUF4782)

    6. NM_001258927.1 → NP_001245856.1  GRAM domain containing 1B, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NE71
      Conserved Domains (1) summary
      pfam16016
      Location:306 → 452
      DUF4782; Domain of unknown function (DUF4782)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYU1 A8DYU1
    A8DYU2 A8DYU2
    A8DYU3 A8DYU3
    M9NE71 M9NE71
    Q8IGN7 Q8IGN7
    Q8MRR1 Q8MRR1
    R9PY34 R9PY34
    R9PY62 R9PY62

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