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    Sytbeta Synaptotagmin beta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39630, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sytbetaprovided by FlyBase
    Official Full Name
    Synaptotagmin betaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261090
    Locus tag
    Dmel_CG42333
    See related
    AllianceGenome:FB:FBgn0261090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13462; CG3020; CG42333; Dmel\CG42333; dsytbeta; Syt beta; Syt V; SYT-beta; syt13; Syt13; sytbeta; SytV
    Old locus tag
    Dmel_CG13462; Dmel_CG3020
    Summary
    Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in regulation of calcium ion-dependent exocytosis and synaptic vesicle exocytosis. Predicted to be located in membrane and synaptic vesicle. Predicted to be active in exocytic vesicle and plasma membrane. Is expressed in several structures, including adult brain cell body rind; adult gnathal ganglion; adult neuromere; synaptic neuropil domain; and synaptic neuropil layer. Orthologous to human SYT13 (synaptotagmin 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sytbeta in Genome Data Viewer
    Location:
    71B1-71B2; 3-42 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15014695..15064977, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15007795..15058077, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Zinc/iron regulated transporter-related protein 71B Neighboring gene Proteasome beta2 subunit Neighboring gene mitochondrial ribosomal protein L39 Neighboring gene Reversion-inducing-cysteine-rich protein with kazal motifs Neighboring gene uncharacterized protein Neighboring gene Regulatory particle non-ATPase 12-related Neighboring gene intermediate neuroblasts defective Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43684 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Enhancer of Acetyltransferase Chameau Neighboring gene uncharacterized protein Neighboring gene Pericentrin-like protein Neighboring gene Odorant receptor 71a Neighboring gene stepping stone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. unfulfilled interacting genes display branch-specific roles in the development of mushroom body axons in Drosophila melanogaster. Bates KE, et al. G3 (Bethesda), 2014 Apr 16. PMID 24558265, Free PMC Article
    2. Peptidergic cell-specific synaptotagmins in Drosophila: localization to dense-core granules and regulation by the bHLH protein DIMMED. Park D, et al. J Neurosci, 2014 Sep 24. PMID 25253864, Free PMC Article
    3. The unfulfilled gene and nervous system development in Drosophila. Bates KE, et al. Biochim Biophys Acta, 2015 Feb. PMID 24953188
    4. piggyBac-based insertional mutagenesis and enhancer detection as a tool for functional insect genomics. Horn C, et al. Genetics, 2003 Feb. PMID 12618403, Free PMC Article
    5. Genetic and molecular analysis of the synaptotagmin family. Adolfsen B, et al. Cell Mol Life Sci, 2001 Mar. PMID 11315187, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptotagmin beta
    Names
    CG42333-PC
    CG42333-PD
    Sytbeta-PC
    Sytbeta-PD
    synaptotagmin V
    sytbeta

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15014695..15064977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144170.2 → NP_652427.2  synaptotagmin beta, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652427.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0AVU5, Q9VUJ6
      Conserved Domains (2) summary
      cd00276
      Location:417 → 545
      C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
      cl14603
      Location:285 → 407
      C2; C2 domain

    2. NM_140477.2 → NP_648734.1  synaptotagmin beta, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648734.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0AVU5, Q9VUJ3
      Related
      FBpp0289127
      Conserved Domains (2) summary
      cd00276
      Location:473 → 601
      C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
      cl14603
      Location:341 → 463
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUJ3 Q9VUJ3
    Q9VUJ6 Q9VUJ6

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