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    dati datilografo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43789, updated on 9-Dec-2024

    Summary

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    Official Symbol
    datiprovided by FlyBase
    Official Full Name
    datilografoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262636
    Locus tag
    Dmel_CG2052
    See related
    AllianceGenome:FB:FBgn0262636
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10204; CG2052; Dmel\CG2052; DmLin29; Lin29
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in adult locomotory behavior; nervous system development; and positive regulation of female receptivity. Predicted to be active in nucleus. Is expressed in several structures, including brain; embryonic abdomen; embryonic pars intercerebralis; larval nervous system; and larval ventral nerve cord. Orthologous to human ZNF142 (zinc finger protein 142). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dati in Genome Data Viewer
    Location:
    102B6-102B7; 4-0 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (375640..395605, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (396266..416231, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene Ring finger protein 11 Neighboring gene plasma membrane calcium ATPase Neighboring gene Host cell factor Neighboring gene long non-coding RNA:CR45125 Neighboring gene antisense RNA:CR44027 Neighboring gene mir-9385 stem loop Neighboring gene long non-coding RNA:CR43437

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel genetic tool for clonal analysis of fourth chromosome mutations. Sousa-Neves R, et al. Fly (Austin), 2012 Jan-Mar. PMID 22198523, Free PMC Article
    2. Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locus. Song Z, et al. Sci China Life Sci, 2021 May. PMID 32815066
    3. The KRÜPPEL-like transcription factor DATILÓGRAFO is required in specific cholinergic neurons for sexual receptivity in Drosophila females. Schinaman JM, et al. PLoS Biol, 2014 Oct. PMID 25291190, Free PMC Article
    4. Neuroblast entry into quiescence is regulated intrinsically by the combined action of spatial Hox proteins and temporal identity factors. Tsuji T, et al. Development, 2008 Dec. PMID 18948419
    5. Molecular and genetic organization of bands and interbands in the dot chromosome of Drosophila melanogaster. Sidorenko DS, et al. Chromosoma, 2019 Jun. PMID 31041520, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. required for proper locomotion and courtship acceptance in adult Drosophila females
      Title: The KRÜPPEL-like transcription factor DATILÓGRAFO is required in specific cholinergic neurons for sexual receptivity in Drosophila females.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c379721-379034 mobile_element_type = transposon:INE-1{}5512
    • Loc: c381698-381620 mobile_element_type = transposon:INE-1{}5513
    • Loc: c392037-391697 mobile_element_type = transposon:INE-1{}5529

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in generation of neurons IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of female receptivity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    datilografo
    Names
    CG2052-PA
    CG2052-PB
    CG2052-PC
    CG2052-PD
    dati-PA
    dati-PB
    dati-PC
    dati-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      375640..395605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258492.3 → NP_001245421.1  datilografo, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245421.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3X3, Q7KQN5
      Conserved Domains (4) summary
      COG5048
      Location:429 → 511
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:441 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:667 → 687
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:454 → 478
      zf-H2C2_2; Zinc-finger double domain

    2. NM_166758.4 → NP_726568.2  datilografo, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726568.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3X3, Q95U52, Q9V4C9
      Related
      FBpp0088197
      Conserved Domains (4) summary
      COG5048
      Location:429 → 587
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:441 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:657 → 677
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:454 → 478
      zf-H2C2_2; Zinc-finger double domain

    3. NM_205874.3 → NP_995596.1  datilografo, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995596.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3X3, Q7KQN5
      Conserved Domains (4) summary
      COG5048
      Location:429 → 511
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:441 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:667 → 687
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:454 → 478
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001258493.2 → NP_001245422.1  datilografo, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245422.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9XVN7
      Conserved Domains (3) summary
      COG5048
      Location:70 → 152
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:82 → 102
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:95 → 119
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H9XVN7 H9XVN7
    Q7K3X3 Q7K3X3
    Q7KQN5 Q7KQN5
    Q9V4C9 Q9V4C9

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