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    Oatp30B Organic anion transporting polypeptide 30B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34268, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Oatp30Bprovided by FlyBase
    Official Full Name
    Organic anion transporting polypeptide 30Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032123
    Locus tag
    Dmel_CG3811
    See related
    AllianceGenome:FB:FBgn0032123
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3811; Dmel\CG3811; oatp 30B; oatp30B
    Summary
    Enables organic anion transmembrane transporter activity. Involved in organic anion transport and transmembrane transport. Located in basolateral plasma membrane. Is expressed in adult head; embryonic/larval proventriculus; eye disc; larval ventral nerve cord; and photoreceptor neurons. Used to study epilepsy. Orthologous to human SLCO5A1 (solute carrier organic anion transporter family member 5A1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Oatp30B in Genome Data Viewer
    Location:
    30B10-30B10; 2-35 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9521210..9540060)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9521210..9540060)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene GDP dissociation inhibitor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 30B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SLCO5A1 and synaptic assembly genes contribute to impulsivity in juvenile myoclonic epilepsy. Roshandel D, et al. NPJ Genom Med, 2023 Sep 28. PMID 37770509, Free PMC Article
    2. Glial Chloride Channels in the Function of the Nervous System Across Species. Fernandez-Abascal J, et al. Adv Exp Med Biol, 2021. PMID 35138616, Free PMC Article
    3. Multidrug transporters and organic anion transporting polypeptides protect insects against the toxic effects of cardenolides. Groen SC, et al. Insect Biochem Mol Biol, 2017 Feb. PMID 28011348, Free PMC Article
    4. Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila. Ayukawa T, et al. Cell Rep, 2014 Jul 24. PMID 24998533
    5. Essential functions of mosquito ecdysone importers in development and reproduction. Hun LV, et al. Proc Natl Acad Sci U S A, 2022 Jun 21. PMID 35696563, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables active transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic anion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    organic anion transporting polypeptide 30B
    Names
    CG3811-PA
    CG3811-PB
    CG3811-PC
    CG3811-PD
    Oatp30B-PA
    Oatp30B-PB
    Oatp30B-PC
    Oatp30B-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9521210..9540060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164857.3 → NP_723463.1  organic anion transporting polypeptide 30B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723463.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLB3
      Related
      FBpp0079423
      Conserved Domains (4) summary
      cd06174
      Location:174 → 433
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:633 → 684
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:171 → 818
      OATP; Organic Anion Transporter Polypeptide (OATP) family
      cl21472
      Location:512 → 600
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    2. NM_135449.4 → NP_609293.2  organic anion transporting polypeptide 30B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609293.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLB3
      Related
      FBpp0079424
      Conserved Domains (4) summary
      cd06174
      Location:174 → 433
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:633 → 684
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:171 → 818
      OATP; Organic Anion Transporter Polypeptide (OATP) family
      cl21472
      Location:512 → 600
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    3. NM_205946.2 → NP_995668.1  organic anion transporting polypeptide 30B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995668.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLB3
      Conserved Domains (4) summary
      cd06174
      Location:174 → 433
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:633 → 684
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:171 → 818
      OATP; Organic Anion Transporter Polypeptide (OATP) family
      cl21472
      Location:512 → 600
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    4. NM_205945.2 → NP_995667.1  organic anion transporting polypeptide 30B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995667.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTG4
      Conserved Domains (5) summary
      cd06174
      Location:113 → 372
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:572 → 623
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:110 → 757
      OATP; Organic Anion Transporter Polypeptide (OATP) family
      pfam04425
      Location:1054 → 1131
      Bul1_N; Bul1 N terminus
      cl21472
      Location:451 → 539
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KTG4 Q7KTG4
    Q8IH70 Q8IH70
    Q9VLB3 Q9VLB3

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