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    Klp31E Kinesin-like protein at 31E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34422, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klp31Eprovided by FlyBase
    Official Full Name
    Kinesin-like protein at 31Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032243
    Locus tag
    Dmel_CG5300
    See related
    AllianceGenome:FB:FBgn0032243
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5300; DmCG5300; Dmel\CG5300; DmKlp31D; DmKlp31E; KIF 21A; KIF21A/B; KLP31E
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Is expressed in organism. Human ortholog(s) of this gene implicated in congenital fibrosis of the extraocular muscles 1. Orthologous to human KIF21A (kinesin family member 21A) and KIF21B (kinesin family member 21B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Klp31E in Genome Data Viewer
    Location:
    31E1-31E1; 2-42 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10414017..10418991)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10414017..10418991)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S27A Neighboring gene Intronic Protein 259 Neighboring gene uncharacterized protein Neighboring gene Replication factor C subunit 3 Neighboring gene pineapple eye

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Three novel mutations in KIF21A highlight the importance of the third coiled-coil stalk domain in the etiology of CFEOM1. Chan WM, et al. BMC Genet, 2007 May 18. PMID 17511870, Free PMC Article
    2. Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1). Yamada K, et al. Nat Genet, 2003 Dec. PMID 14595441
    3. Msps governs acentrosomal microtubule assembly and reactivation of quiescent neural stem cells. Deng Q, et al. EMBO J, 2021 Oct 1. PMID 34368973, Free PMC Article
    4. A kinesin family tree. Kim AJ, et al. J Cell Sci, 2000 Nov. PMID 11034894
    5. A new kinesin tree. Dagenbach EM, et al. J Cell Sci, 2004 Jan 1. PMID 14657268

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Kinesin-like protein at 31E
    Names
    CG5300-PA
    CG5300-PB
    CG5300-PC
    CG5300-PE
    Kinesin3D
    Klp31E-PA
    Klp31E-PB
    Klp31E-PC
    Klp31E-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10414017..10418991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135554.3 → NP_609398.2  Kinesin-like protein at 31E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609398.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NGN7, Q9VKW4
      Related
      FBpp0079608
      Conserved Domains (4) summary
      smart00129
      Location:13 → 370
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01372
      Location:12 → 364
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam14662
      Location:409 → 589
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      cl02569
      Location:685 → 750
      RasGAP; Ras GTPase Activating Domain

    2. NM_001169466.2 → NP_001162937.2  Kinesin-like protein at 31E, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162937.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHE1, Q9NGN7
      Conserved Domains (3) summary
      smart00129
      Location:13 → 370
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01372
      Location:12 → 364
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      cl02569
      Location:684 → 749
      RasGAP; Ras GTPase Activating Domain

    3. NM_001169465.2 → NP_001162936.1  Kinesin-like protein at 31E, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162936.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NGN7, Q9VKW4
      Conserved Domains (4) summary
      smart00129
      Location:13 → 370
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01372
      Location:12 → 364
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam14662
      Location:409 → 589
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      cl02569
      Location:685 → 750
      RasGAP; Ras GTPase Activating Domain

    4. NM_001169464.1 → NP_001162935.1  Kinesin-like protein at 31E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162935.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NGN7, Q9VKW4
      Conserved Domains (4) summary
      smart00129
      Location:13 → 370
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01372
      Location:12 → 364
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam14662
      Location:409 → 589
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      cl02569
      Location:685 → 750
      RasGAP; Ras GTPase Activating Domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHE1 E1JHE1
    Q9NGN7 Q9NGN7
    Q9VKW4 Q9VKW4

    Gene LinkOut

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