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    nuf nuclear fallout [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39572, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nufprovided by FlyBase
    Official Full Name
    nuclear falloutprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013718
    Locus tag
    Dmel_CG33991
    See related
    AllianceGenome:FB:FBgn0013718
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-D2; CG32140; CG33991; CG3779; CG7867; CIP-D2; Cy3-23; D2; Dmel\CG33991; EP3077; FIP3; Nuf; NUF; Nuf1; Nuf2p
    Summary
    Involved in actin cytoskeleton organization; sensory organ precursor cell fate determination; and wing disc dorsal/ventral pattern formation. Located in apical cortex and perinuclear region of cytoplasm. Colocalizes with centrosome. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; head epidermis primordium; and visceral mesoderm derivative. Orthologous to human RAB11FIP3 (RAB11 family interacting protein 3) and RAB11FIP4 (RAB11 family interacting protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nuf in Genome Data Viewer
    Location:
    70D3-70D4; 3-42 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14190870..14233250)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14183970..14226350)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Dichaete Neighboring gene nanchung Neighboring gene saturn Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuf and Rip11 requirement for polarity determinant recycling during Drosophila development. Calero-Cuenca FJ, et al. Small GTPases, 2018 Jul 4. PMID 27687567, Free PMC Article
    2. Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout. Hickson GR, et al. Mol Biol Cell, 2003 Jul. PMID 12857874, Free PMC Article
    3. Polo kinase mediates the phosphorylation and cellular localization of Nuf/FIP3, a Rab11 effector. Brose L, et al. Mol Biol Cell, 2017 Jun 1. PMID 28381422, Free PMC Article
    4. Nuclear-fallout, a Drosophila protein that cycles from the cytoplasm to the centrosomes, regulates cortical microfilament organization. Rothwell WF, et al. Development, 1998 Apr. PMID 9477328
    5. A mitotic kinesin-6, Pav-KLP, mediates interdependent cortical reorganization and spindle dynamics in Drosophila embryos. Sommi P, et al. J Cell Sci, 2010 Jun 1. PMID 20442250, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. aPKC interacts and phosphorylates nuclear fallout.
      Title: Nuclear fallout provides a new link between aPKC and polarized cell trafficking.
    2. In nuf mutant embryos, an initial loss of F-actin at the furrow is followed by loss of the associated furrow membrane.
      Title: Nuf, a Rab11 effector, maintains cytokinetic furrow integrity by promoting local actin polymerization.
    3. The cell cycle-regulated, Dynein-dependent recruitment of Nuf to the microtubule-organizing center influences the timing of recycling endosome-based vesicle delivery to the invaginating furrows.
      Title: The concentration of Nuf, a Rab11 effector, at the microtubule-organizing center is cell cycle regulated, dynein-dependent, and coincides with furrow formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory organ precursor cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nuclear fallout
    Names
    CG33991-PA
    CG33991-PB
    CG33991-PC
    CG33991-PD
    CG33991-PE
    CG33991-PF
    CG33991-PG
    CG33991-PH
    CG33991-PJ
    CG33991-PK
    CG33991-PL
    CG33991-PM
    corkscrew interacting Protein-D2
    nuclear-fallout
    nuf-PA
    nuf-PB
    nuf-PC
    nuf-PD
    nuf-PE
    nuf-PF
    nuf-PG
    nuf-PH
    nuf-PJ
    nuf-PK
    nuf-PL
    nuf-PM

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14190870..14233250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259820.2 → NP_001246749.1  nuclear fallout, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246749.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMM7, M9NDQ8
      Conserved Domains (3) summary
      pfam09457
      Location:485 → 525
      RBD-FIP; FIP domain
      pfam09798
      Location:350 → 437
      LCD1; DNA damage checkpoint protein
      cl02193
      Location:425 → 495
      VirB5_like; VirB5 protein family

    2. NM_001259821.2 → NP_001246750.1  nuclear fallout, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246750.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMM7, M9NE94
      Conserved Domains (3) summary
      pfam09457
      Location:484 → 524
      RBD-FIP; FIP domain
      pfam09798
      Location:349 → 436
      LCD1; DNA damage checkpoint protein
      cl02193
      Location:424 → 494
      VirB5_like; VirB5 protein family

    3. NM_001038920.2 → NP_001034009.1  nuclear fallout, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034009.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYQ0, Q9VUD7
      Conserved Domains (3) summary
      pfam09457
      Location:457 → 497
      RBD-FIP; FIP domain
      pfam09798
      Location:335 → 422
      LCD1; DNA damage checkpoint protein
      cl02193
      Location:410 → 467
      VirB5_like; VirB5 protein family

    4. NM_001259824.1 → NP_001246753.1  nuclear fallout, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246753.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFB8, Q8SYQ0
      Conserved Domains (3) summary
      pfam09457
      Location:470 → 510
      RBD-FIP; FIP domain
      pfam09798
      Location:335 → 422
      LCD1; DNA damage checkpoint protein
      cl02193
      Location:410 → 480
      VirB5_like; VirB5 protein family

    5. NM_001038922.2 → NP_001034011.1  nuclear fallout, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034011.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYQ0, Q9VUD7
      Conserved Domains (3) summary
      pfam09457
      Location:457 → 497
      RBD-FIP; FIP domain
      pfam09798
      Location:335 → 422
      LCD1; DNA damage checkpoint protein
      cl02193
      Location:410 → 467
      VirB5_like; VirB5 protein family

    6. NM_001259819.2 → NP_001246748.1  nuclear fallout, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246748.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFB1
      Conserved Domains (2) summary
      PRK10929
      Location:20 → 185
      PRK10929; putative mechanosensitive channel protein; Provisional
      pfam09457
      Location:273 → 313
      RBD-FIP; FIP domain

    7. NM_001038918.1 → NP_001034007.1  nuclear fallout, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034007.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0E0
      Conserved Domains (1) summary
      pfam09457
      Location:260 → 300
      RBD-FIP; FIP domain

    8. NM_001259822.2 → NP_001246751.1  nuclear fallout, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246751.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9ND89
      Conserved Domains (2) summary
      pfam09457
      Location:496 → 536
      RBD-FIP; FIP domain
      cl02193
      Location:436 → 506
      VirB5_like; VirB5 protein family

    9. NM_001038919.2 → NP_001034008.1  nuclear fallout, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034008.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN29
      Conserved Domains (2) summary
      pfam09457
      Location:483 → 523
      RBD-FIP; FIP domain
      cl02193
      Location:436 → 493
      VirB5_like; VirB5 protein family

    10. NM_001259823.2 → NP_001246752.1  nuclear fallout, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246752.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9ND89
      Conserved Domains (2) summary
      pfam09457
      Location:496 → 536
      RBD-FIP; FIP domain
      cl02193
      Location:436 → 506
      VirB5_like; VirB5 protein family

    11. NM_001038917.2 → NP_001034006.1  nuclear fallout, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034006.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN29
      Conserved Domains (2) summary
      pfam09457
      Location:483 → 523
      RBD-FIP; FIP domain
      cl02193
      Location:436 → 493
      VirB5_like; VirB5 protein family

    12. NM_001038921.2 → NP_001034010.1  nuclear fallout, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034010.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUK1
      Conserved Domains (1) summary
      pfam09457
      Location:271 → 311
      RBD-FIP; FIP domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9ND89 M9ND89
    M9NDQ8 M9NDQ8
    M9NE94 M9NE94
    M9NFB1 M9NFB1
    M9NFB8 M9NFB8
    O61495 O61495
    Q6NN29 Q6NN29
    Q7KUK1 Q7KUK1
    Q8SYQ0 Q8SYQ0
    Q8T0E0 Q8T0E0
    Q9VUD7 Q9VUD7

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