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    U3-55K U3 small nuclear riboprotein factor 55K [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3346176, updated on 9-Dec-2024

    Summary

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    Official Symbol
    U3-55Kprovided by FlyBase
    Official Full Name
    U3 small nuclear riboprotein factor 55Kprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053505
    Locus tag
    Dmel_CG33505
    See related
    AllianceGenome:FB:FBgn0053505
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10220; CG33505; Dmel\CG33505
    Summary
    Enables U3 snoRNA binding activity. Predicted to be located in nucleolus. Predicted to be part of box C/D methylation guide snoRNP complex and small-subunit processome. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; mesoderm; and visceral mesoderm derivative. Orthologous to human RRP9 (ribosomal RNA processing 9, U3 small nucleolar RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See U3-55K in Genome Data Viewer
    Location:
    51C5-51C5; 2-72 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14858845..14860758, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10746350..10748263, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ercc1 Neighboring gene Ciao1 Neighboring gene Hermansky-Pudlak Syndrome 1 Neighboring gene uncharacterized protein Neighboring gene Pcf11 cleavage and polyadenylation factor subunit Neighboring gene Cytochrome P450 6a22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles. Tycowski KT, et al. Mol Cell, 2009 Apr 10. PMID 19285445, Free PMC Article
    2. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article
    3. Comparative interactome analysis of α-arrestin families in human and Drosophila. Lee KT, et al. Elife, 2024 Jan 25. PMID 38270169, Free PMC Article
    4. Latitudinal clines in gene expression and cis-regulatory element variation in Drosophila melanogaster. Juneja P, et al. BMC Genomics, 2016 Nov 28. PMID 27894253, Free PMC Article
    5. Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet. Çiçek IÖ, et al. Genetics, 2016 Mar. PMID 26801178, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables U3 snoRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables U3 snoRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of box C/D methylation guide snoRNP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    U3 small nuclear riboprotein factor 55K
    Names
    CG33505-PA
    U3-55K-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14858845..14860758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014529.3 → NP_001014529.1  U3 small nuclear riboprotein factor 55K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014529.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSW9
      Conserved Domains (4) summary
      COG2319
      Location:150 → 484
      WD40; WD40 repeat [General function prediction only]
      pfam04050
      Location:55 → 125
      Upf2; Up-frameshift suppressor 2
      sd00039
      Location:163 → 203
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:156 → 416
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSW9 Q8MSW9

    Gene LinkOut

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