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    Usp10 Ubiquitin specific protease 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38103, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Usp10provided by FlyBase
    Official Full Name
    Ubiquitin specific protease 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0052479
    Locus tag
    Dmel_CG32479
    See related
    AllianceGenome:FB:FBgn0052479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12503; CG13903; CG32479; Dmel\CG32479; Q9W0L7; usp10; USP10
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Involved in positive regulation of Notch signaling pathway. Located in cytosol. Is expressed in adult brain cell body rind and adult head. Orthologous to human USP10 (ubiquitin specific peptidase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Usp10 in Genome Data Viewer
    Location:
    61D2-61D4; 3-0.5 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (871899..895313)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (871899..895313)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene defective proboscis extension response 20 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Usp10 Modulates the Hippo Pathway by Deubiquitinating and Stabilizing the Transcriptional Coactivator Yorkie. Gao Y, et al. Int J Mol Sci, 2019 Nov 29. PMID 31795326, Free PMC Article
    2. The ubiquitin thioesterase YOD1 ameliorates mutant Huntingtin induced pathology in Drosophila. Farkas A, et al. Sci Rep, 2023 Dec 11. PMID 38081944, Free PMC Article
    3. RNA-binding protein Roquin negatively regulates STING-dependent innate immune response in Drosophila. Du BB, et al. Yi Chuan, 2020 Dec 17. PMID 33509784
    4. fat facets induces polyubiquitination of Imd and inhibits the innate immune response in Drosophila. Yagi Y, et al. Genes Cells, 2013 Nov. PMID 23919485
    5. In vivo Structure/Function analysis of the Drosophila fat facets deubiquitinating enzyme gene. Chen X, et al. Genetics, 2000 Dec. PMID 11102377, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NELF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    ubiquitin specific protease 10
    Names
    CG32479-PA
    CG32479-PB
    CG32479-PC
    Usp10-PA
    Usp10-PB
    Usp10-PC
    NP_001261228.1
    NP_001261229.1
    NP_728554.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      871899..895313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167844.2 → NP_728554.1  ubiquitin specific protease 10, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728554.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0L7
      Related
      FBpp0072486
      Conserved Domains (2) summary
      cd02257
      Location:1223 → 1480
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:1109 → 1479
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. NM_001274300.1 → NP_001261229.1  ubiquitin specific protease 10, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261229.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0L7
      Conserved Domains (2) summary
      cd02257
      Location:1223 → 1480
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:1109 → 1479
      UCH; Ubiquitin carboxyl-terminal hydrolase

    3. NM_001274299.1 → NP_001261228.1  ubiquitin specific protease 10, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261228.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDK3
      Conserved Domains (2) summary
      cd02257
      Location:503 → 760
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:389 → 759
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDK3 M9PDK3
    Q9W0L7 Q9W0L7

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