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    RecQ5 RecQ5 helicase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39594, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RecQ5provided by FlyBase
    Official Full Name
    RecQ5 helicaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027375
    Locus tag
    Dmel_CG4879
    See related
    AllianceGenome:FB:FBgn0027375
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey293; CG4879; Dm RECQ5/QE; Dmel\CG4879; DmRECQ5; dmRecQ5b; Dq1; DQ1; dRecQ5; Q1; recq5; RECQ5; RECQ5/QE; RECQE
    Summary
    Enables GTP binding activity; GTPase activity; and single-stranded DNA helicase activity. Involved in several processes, including double-strand break repair via single-strand annealing; mitotic sister chromatid segregation; and response to X-ray. Located in nucleus. Is expressed in nurse cell; oocyte; organism; and spermatozoon. Orthologous to human RECQL5 (RecQ like helicase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RecQ5 in Genome Data Viewer
    Location:
    70E5-70E5; 3-42 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14628160..14632077, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14621260..14625177, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene HGTX Neighboring gene shade Neighboring gene uncharacterized protein Neighboring gene dally-like Neighboring gene long non-coding RNA:CR45888 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of Drosophila melanogaster RECQE as a member of a new family of RecQ homologues that is preferentially expressed in early embryos. Jeong SM, et al. Mol Gen Genet, 2000 Mar. PMID 10778736
    2. Biochemical characterization of the small isoform of Drosophila melanogaster RECQ5 helicase. Ozsoy AZ, et al. Nucleic Acids Res, 2001 Jul 15. PMID 11452023, Free PMC Article
    3. Drosophila melanogaster RECQ5/QE DNA helicase: stimulation by GTP binding. Kawasaki K, et al. Nucleic Acids Res, 2002 Sep 1. PMID 12202752, Free PMC Article
    4. Analysis of helicase activity and substrate specificity of Drosophila RECQ5. Ozsoy AZ, et al. Nucleic Acids Res, 2003 Mar 1. PMID 12595564, Free PMC Article
    5. Drosophila RecQ5 is required for efficient SSA repair and suppression of LOH in vivo. Chen Y, et al. Protein Cell, 2010 May. PMID 21203963, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Therefore, Drosophila RecQ5 may contribute to the proper progression from germline stem cells to spermatocytes for maintenance of genome stability.
      Title: Drosophila RecQ5 is involved in proper progression of early spermatogenesis.
    2. RecQ5 protein was translocated into the nucleus by an nuclear localization signal.
      Title: RecQ5 protein translocation into the nucleus by a nuclear localization signal.
    3. Lack of RecQ5 causes spontaneous double-strand DNA breaks. RecQ5 may thus function in the resolution of anaphase DNA bridges during mitosis in syncytial embryo.(review)
      Title: [Role of RecQ5 in syncytial blastoderm of the Drosophila embryo].
    4. The data demonstrate that dRecQ5 functions in SSA-mediated DSB repair to achieve its full efficiency and in suppression of LOH in Drosophila.
      Title: Drosophila RecQ5 is required for efficient SSA repair and suppression of LOH in vivo.
    5. lack of RecQ5 leads to spontaneous double-stranded DNA breaks
      Title: Anaphase DNA bridges induced by lack of RecQ5 in Drosophila syncytial embryos.
    6. DNA damage accumulates spontaneously in RecQ5 mutants.
      Title: Loss of RecQ5 leads to spontaneous mitotic defects and chromosomal aberrations in Drosophila melanogaster.
    7. RECQ5/QE interacts with components of the cell-cycle during its progression in response to DNA damage
      Title: Relationships of Drosophila melanogaster RECQ5/QE to cell-cycle progression and DNA damage.
    8. WRN, BLM, and dmRecQ5b have a novel strand pairing capability that, when coordinated with the well established helicase activity, endows these RecQ helicases with a strand exchange function
      Title: RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c14630465-14630298 mobile_element_type = transposon:INE-1{}3277

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables four-way junction helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via single-strand annealing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to X-ray IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RecQ5 helicase
    Names
    CG4879-PA
    CG4879-PB
    CG4879-PC
    RecQ5-PA
    RecQ5-PB
    RecQ5-PC
    drosophila homolog of RecQ
    homolog of RecQ
    NP_001014584.1
    NP_524070.2
    NP_729983.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14628160..14632077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168591.3 → NP_729983.1  RecQ5 helicase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729983.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V433, R4NTS1
      Related
      FBpp0075458
      Conserved Domains (4) summary
      COG0514
      Location:6 → 442
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
      cd00079
      Location:257 → 359
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:37 → 193
      DEAD; DEAD/DEAH box helicase
      pfam16124
      Location:364 → 431
      RecQ_Zn_bind; RecQ zinc-binding

    2. NM_001014584.3 → NP_001014584.1  RecQ5 helicase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014584.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59E27, Q9UA31
      Conserved Domains (4) summary
      COG0514
      Location:6 → 442
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
      cd00079
      Location:257 → 359
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:37 → 193
      DEAD; DEAD/DEAH box helicase
      pfam16124
      Location:364 → 431
      RecQ_Zn_bind; RecQ zinc-binding

    3. NM_079346.4 → NP_524070.2  RecQ5 helicase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524070.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZ98, Q9UA32
      Related
      FBpp0075457
      Conserved Domains (4) summary
      COG0514
      Location:6 → 442
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
      cd00079
      Location:257 → 359
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:37 → 193
      DEAD; DEAD/DEAH box helicase
      pfam16124
      Location:364 → 431
      RecQ_Zn_bind; RecQ zinc-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q59E27 Q59E27
    Q7YZ98 Q7YZ98
    Q95U81 Q95U81
    Q9U5E0 Q9U5E0
    Q9UA31 Q9UA31
    Q9UA32 Q9UA32
    Q9V433 Q9V433
    Q9Y1H2 Q9Y1H2

    Gene LinkOut

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