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    Hrb87F Heterogeneous nuclear ribonucleoprotein at 87F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48535, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hrb87Fprovided by FlyBase
    Official Full Name
    Heterogeneous nuclear ribonucleoprotein at 87Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004237
    Locus tag
    Dmel_CG12749
    See related
    AllianceGenome:FB:FBgn0004237
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12749; Dmel\CG12749; hnRNP A2/B1; hnRNP36; hnRNPA1; hnRNPA1/A2; hnRNPA2; hnRNPA2/B1; Hrb2; Hrb85CD; hrb87f; Hrb87f; HRB87F; HRB87F/hrp36; Hrb87Fa; hrp36; Hrp36; HRP36; P11; P11/Hrb87F; p38; Q14; Q16
    Summary
    Enables sequence-specific DNA binding activity. Involved in several processes, including female gonad development; regulation of alternative mRNA splicing, via spliceosome; and response to heat. Located in heterochromatin; omega speckle; and polytene chromosome puff. Part of ribonucleoprotein complex. Is expressed in adult head; adult heart; larval midline neurons; and ovary. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; distal myopathy 3; inclusion body myopathy with Paget disease of bone and frontotemporal dementia (multiple); and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hrb87F in Genome Data Viewer
    Location:
    87F7-87F7; 3-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13656846..13660531, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9482568..9486253, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene rasputin Neighboring gene RNA-binding protein 4 Neighboring gene B52 Neighboring gene TWIK-related acid-sensitive K[+] channel 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Hrb loci: a family of hnRNA binding proteins. Haynes SR, et al. Mol Biol Rep, 1990. PMID 2113991
    2. Therapeutic reduction of GGGGCC repeat RNA levels by hnRNPA3 suppresses neurodegeneration in Drosophila models of C9orf72-linked ALS/FTD. Taminato T, et al. Hum Mol Genet, 2023 May 5. PMID 36611007
    3. ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity. An H, et al. Neurobiol Dis, 2022 Jan. PMID 34915152, Free PMC Article
    4. Drosophila snRNP associated protein P11 which specifically binds to heat shock puff 93D reveals strong homology with hnRNP core protein A1. Hovemann BT, et al. Nucleic Acids Res, 1991 Sep 25. PMID 1717937, Free PMC Article
    5. Camptothecin (CPT) directly binds to human heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and inhibits the hnRNP A1/topoisomerase I interaction. Manita D, et al. Bioorg Med Chem, 2011 Dec 15. PMID 22071521

    See all (150) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The hnRNP A1 homolog Hrb87F/Hrp36 is important for telomere maintenance in Drosophila melanogaster.
      Title: The hnRNP A1 homolog Hrb87F/Hrp36 is important for telomere maintenance in Drosophila melanogaster.
    2. Hrp36 is essential for normal development and for survival under conditions of stress
      Title: The hnRNP A1 homolog Hrp36 is essential for normal development, female fecundity, omega speckle formation and stress tolerance in Drosophila melanogaster.
    3. shows that the heterogeneous nuclear ribonucleoprotein hrp36 acts specifically within, and throughout, the exon 6 cluster to prevent the inclusion of multiple exons.
      Title: A regulator of Dscam mutually exclusive splicing fidelity.
    4. direct and indirect interactions of the hsromega transcripts with a variety of regulatory proteins like hnRNPs, CBP, proteasome, Drosophila inhibitor of apoptosis protein 1 (DIAP1)
      Title: Improved activities of CREB binding protein, heterogeneous nuclear ribonucleoproteins and proteasome following downregulation of noncoding hsromega transcripts help suppress poly(Q) pathogenesis in fly models.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables poly(G) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in compound eye morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in female gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle HMP PubMed 
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in omega speckle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome puff IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein at 87F
    Names
    CG12749-PA
    CG12749-PC
    CG12749-PD
    CG12749-PE
    Hrb87F-PA
    Hrb87F-PC
    Hrb87F-PD
    Hrb87F-PE
    heterogeneous nuclear ribonucleoprotein at 85CD
    hnRNA-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13656846..13660531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275609.1 → NP_001262538.1  heterogeneous nuclear ribonucleoprotein at 87F, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262538.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48810, Q24486, Q8INH0, Q9VFT2
      UniProtKB/TrEMBL
      E1JIK0
      Conserved Domains (2) summary
      cd12578
      Location:25 → 102
      RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:116 → 188
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_057458.5 → NP_476806.2  heterogeneous nuclear ribonucleoprotein at 87F, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476806.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48810, Q24486, Q8INH0, Q9VFT2
      UniProtKB/TrEMBL
      E1JIK0
      Conserved Domains (2) summary
      cd12578
      Location:25 → 102
      RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:116 → 188
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_057459.5 → NP_476807.1  heterogeneous nuclear ribonucleoprotein at 87F, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476807.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48810, Q24486, Q8INH0, Q9VFT2
      UniProtKB/TrEMBL
      E1JIK0
      Related
      FBpp0082316
      Conserved Domains (2) summary
      cd12578
      Location:25 → 102
      RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:116 → 188
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_001170131.2 → NP_001163602.1  heterogeneous nuclear ribonucleoprotein at 87F, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163602.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48810, Q24486, Q8INH0, Q9VFT2
      UniProtKB/TrEMBL
      E1JIK0
      Conserved Domains (2) summary
      cd12578
      Location:25 → 102
      RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:116 → 188
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIK0 E1JIK0
    P48810.2 P48810

    Gene LinkOut

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