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    AsnRS Asparaginyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35194, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AsnRSprovided by FlyBase
    Official Full Name
    Asparaginyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086443
    Locus tag
    Dmel_CG10687
    See related
    AllianceGenome:FB:FBgn0086443
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aats-asn; BcDNA:GH06451; Ca; CG10687; Dmel\CG10687; l(2)37Ca; l(2)37Ca)E11; l(2)E11; NRS; SN2-8
    Summary
    Predicted to enable asparagine-tRNA ligase activity. Predicted to be involved in asparaginyl-tRNA aminoacylation. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic/larval salivary gland; organism; and spermatozoon. Orthologous to human NARS1 (asparaginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AsnRS in Genome Data Viewer
    Location:
    37C1-37C1; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19129469..19131954, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19129469..19131954, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lethal (2) 37Cb Neighboring gene lethal (2) 37Cd Neighboring gene Dynactin 6, p27 subunit Neighboring gene RNA polymerase I and III subunit D Neighboring gene brain tumor Neighboring gene long non-coding RNA:CR44977

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental control of transduced dopa decarboxylase genes in D. melanogaster. Marsh JL, et al. Mol Gen Genet, 1985. PMID 2989656
    2. A diphenol oxidase gene is part of a cluster of genes involved in catecholamine metabolism and sclerotization in Drosophila. II. Molecular localization of the Dox-A2 coding region. Pentz ES, et al. Genetics, 1986 Apr. PMID 3007281, Free PMC Article
    3. Molecular mapping of a gene cluster flanking the Drosophila Dopa decarboxylase gene. Gilbert D, et al. Genetics, 1984 Apr. PMID 6425116, Free PMC Article
    4. The genetics of dopa decarboxylase in Drosophila melanogaster. IV. The genetics and cytology of the 37B10-37D1 region. Wright TR, et al. Chromosoma, 1981. PMID 6790250
    5. Effects of Ddc cluster lethal alleles on ovary growth, attachment, and egg production in Drosophila. McCrady E, et al. J Exp Zool, 1994 May 1. PMID 8176361

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables asparagine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparagine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables asparagine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in asparaginyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asparaginyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in asparaginyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Asparaginyl-tRNA synthetase
    Names
    AsnRS-PA
    AsnRS-PB
    CG10687-PA
    CG10687-PB
    asparaginyl-tRNA synthetase
    lethal (2) 37Ca
    suppressor of NA9 2-8
    NP_001260561.1
    NP_609948.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19129469..19131954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273632.1 → NP_001260561.1  Asparaginyl-tRNA synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260561.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V434
      Conserved Domains (3) summary
      COG0017
      Location:122 → 558
      AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00776
      Location:233 → 552
      AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
      cd04323
      Location:137 → 219
      AsnRS_cyto_like_N; AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a ...

    2. NM_136104.4 → NP_609948.1  Asparaginyl-tRNA synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609948.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V434
      Related
      FBpp0080705
      Conserved Domains (3) summary
      COG0017
      Location:122 → 558
      AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00776
      Location:233 → 552
      AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
      cd04323
      Location:137 → 219
      AsnRS_cyto_like_N; AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V434 Q9V434

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