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    CG18284 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34460, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG18284provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0043825
    Locus tag
    Dmel_CG18284
    See related
    AllianceGenome:FB:FBgn0043825
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Acp; BEST:GH10507; Dmel\CG18284
    Summary
    Predicted to enable triacylglycerol lipase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head and male accessory gland. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG18284 in Genome Data Viewer
    Location:
    32A2-32A2; 2-43 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10643971..10645891)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10643971..10645891)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45351 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44580

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative structural modeling and inference of conserved protein classes in Drosophila seminal fluid. Mueller JL, et al. Proc Natl Acad Sci U S A, 2004 Sep 14. PMID 15345744, Free PMC Article
    2. Comparative and functional genomics of lipases in holometabolous insects. Horne I, et al. Insect Biochem Mol Biol, 2009 Aug. PMID 19540341
    3. Seminal influences: Drosophila Acps and the molecular interplay between males and females during reproduction. Ravi Ram K, et al. Integr Comp Biol, 2007 Sep. PMID 21672851
    4. A genomic analysis of Drosophila somatic sexual differentiation and its regulation. Arbeitman MN, et al. Development, 2004 May. PMID 15056610
    5. Cross-species comparison of Drosophila male accessory gland protein genes. Mueller JL, et al. Genetics, 2005 Sep. PMID 15944345, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG18284-PB
    CG18284-PC
    NP_001285807.1
    NP_609428.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10643971..10645891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298878.1 → NP_001285807.1  uncharacterized protein Dmel_CG18284, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285807.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U37, Q9VKS9
      Conserved Domains (3) summary
      PLN02872
      Location:101 → 450
      PLN02872; triacylglycerol lipase
      pfam04083
      Location:99 → 150
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:135 → 250
      Abhydrolase_5; Alpha/beta hydrolase family

    2. NM_135584.4 → NP_609428.1  uncharacterized protein Dmel_CG18284, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609428.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U37, Q9VKS9
      Related
      FBpp0290029
      Conserved Domains (3) summary
      PLN02872
      Location:101 → 450
      PLN02872; triacylglycerol lipase
      pfam04083
      Location:99 → 150
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:135 → 250
      Abhydrolase_5; Alpha/beta hydrolase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKS9 Q9VKS9

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