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    Rab18 Rab18 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44360, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rab18provided by FlyBase
    Official Full Name
    Rab18provided by FlyBase
    Primary source
    FLYBASE:FBgn0015794
    Locus tag
    Dmel_CG3129
    See related
    AllianceGenome:FB:FBgn0015794
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    24639915; AAF46057; CG3129; Dmel\CG3129; DmRab18; DRABR4; DRabRP4; O18337; Rab-r4; Rab-RP4; rab18; Rab18/RP4
    Summary
    Predicted to enable GTPase activity. Involved in macroautophagy. Located in Golgi apparatus; endoplasmic reticulum; and vacuole. Is expressed in several structures, including adult ensheathing glial cell; brain; imaginal disc; mushroom body; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in Warburg micro syndrome 3. Orthologous to human RAB18 (RAB18, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rab18 in Genome Data Viewer
    Location:
    5A11-5A11; 1-12 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5670827..5671812, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5564860..5565845, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45520 Neighboring gene Sirtuin 4 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L35 Neighboring gene Trapped in endoderm 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Rab14 mediates phagocytosis in the immune response to Staphylococcus aureus. Garg A, et al. Cell Microbiol, 2014 Feb. PMID 24119134, Free PMC Article
    2. The Warburg Micro Syndrome-associated Rab3GAP-Rab18 module promotes autolysosome maturation through the Vps34 Complex I. Takáts S, et al. FEBS J, 2021 Jan. PMID 32248620
    3. Rab proteins of Drosophila melanogaster: novel members of the Rab-protein family. Satoh AK, et al. FEBS Lett, 1997 Mar 3. PMID 9074639
    4. Formation and function of a highly specialised type of organelle in cardiac valve cells. Meyer C, et al. Development, 2022 Oct 1. PMID 36189830
    5. Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo. White JA 2nd, et al. Hum Mol Genet, 2015 Dec 20. PMID 26450517, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid droplet organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in autolysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome HDA PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body HDA PubMed 
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Rab18
    Names
    CG3129-PA
    Rab18-PA
    rab-related protein 4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5670827..5671812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080005.4 → NP_524744.2  Rab18 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524744.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18337, Q9W4A0
      Related
      FBpp0070814
      Conserved Domains (2) summary
      smart00175
      Location:6 → 166
      RAB; Rab subfamily of small GTPases
      cd01863
      Location:6 → 165
      Rab18; Rab GTPase family 18 (Rab18)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18337 O18337
    Q9W4A0 Q9W4A0

    Gene LinkOut

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