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    l(2)k05819 lethal (2) k05819 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33644, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(2)k05819provided by FlyBase
    Official Full Name
    lethal (2) k05819provided by FlyBase
    Primary source
    FLYBASE:FBgn0022153
    Locus tag
    Dmel_CG3054
    See related
    AllianceGenome:FB:FBgn0022153
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.156; CG3054; Dmel\CG3054
    Summary
    Is expressed in adult head; embryonic/larval midgut; larval muscle system; and organism. Orthologous to human TMEM94 (transmembrane protein 94). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(2)k05819 in Genome Data Viewer
    Location:
    24E5-24F1; 2-12 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4394196..4400487)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4394196..4400487)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Partner of Sld Five 2 Neighboring gene Trehalose-6-phosphate synthase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dim1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A small genomic region containing several loci required for gastrulation in Drosophila. Mathew SJ, et al. PLoS One, 2009 Oct 13. PMID 19823683, Free PMC Article
    2. Network analyses reveal novel aspects of ALS pathogenesis. Sanhueza M, et al. PLoS Genet, 2015 Mar. PMID 25826266, Free PMC Article
    3. A genome-wide resource for the analysis of protein localisation in Drosophila. Sarov M, et al. Elife, 2016 Feb 20. PMID 26896675, Free PMC Article
    4. The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Arya GH, et al. Chem Senses, 2015 May. PMID 25687947, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables P-type magnesium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in magnesium ion transport from cytosol to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lethal (2) k05819
    Names
    CG3054-PA
    CG3054-PC
    CG3054-PD
    l(2)k05819-PA
    l(2)k05819-PC
    l(2)k05819-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4394196..4400487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273094.1 → NP_001260023.1  lethal (2) k05819, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260023.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KU45
      Conserved Domains (1) summary
      cl02929
      Location:1224 → 1407
      Cation_ATPase_C; Cation transporting ATPase, C-terminus

    2. NM_164582.3 → NP_722974.1  lethal (2) k05819, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722974.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQZ1
      Related
      FBpp0077122
      Conserved Domains (1) summary
      cl02929
      Location:1239 → 1422
      Cation_ATPase_C; Cation transporting ATPase, C-terminus

    3. NM_134985.4 → NP_608829.2  lethal (2) k05819, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608829.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KU45
      Conserved Domains (1) summary
      cl02929
      Location:1224 → 1407
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KU45 Q7KU45
    Q961P5 Q961P5
    Q9VQZ1 Q9VQZ1

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