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    DEF8 differentially expressed in FDCP 8 homolog [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39381, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DEF8provided by FlyBase
    Official Full Name
    differentially expressed in FDCP 8 homologprovided by FlyBase
    Primary source
    FLYBASE:FBgn0046296
    Locus tag
    Dmel_CG11534
    See related
    AllianceGenome:FB:FBgn0046296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH12489; CG11534; Def8; Dmel\CG11534
    Summary
    Is expressed in organism. Orthologous to human DEF8 (differentially expressed in FDCP 8 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DEF8 in Genome Data Viewer
    Location:
    68F5-68F5; 3-38 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12132146..12133834)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12125246..12126934)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR11538 Neighboring gene uncharacterized protein Neighboring gene Larval serum protein 2 Neighboring gene antisense RNA:CR45892 Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 12 Neighboring gene NADH dehydrogenase (ubiquinone) SGDH subunit Neighboring gene Rho GTPase activating protein at 68F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of novel plekhm1 and def8 mutant alleles in Drosophila. Maruzs T, et al. Biol Futur, 2022 Jun. PMID 35507305
    2. Evidence for a gene involved in multiple and diverse rearrangements in the Drosophila genus. Puerma E, et al. Mol Biol Evol, 2014 Nov. PMID 25135946
    3. The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains. Oyarce-Pezoa S, et al. Sci Rep, 2023 Oct 10. PMID 37816871, Free PMC Article
    4. Small heat shock proteins determine synapse number and neuronal activity during development. Santana E, et al. PLoS One, 2020. PMID 32437379, Free PMC Article
    5. An in vivo RNAi mini-screen in Drosophila cancer models reveals novel potential Wnt targets in liver cancer. Even İ, et al. Turk J Gastroenterol, 2019 Feb. PMID 30541713, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    differentially expressed in FDCP 8 homolog
    Names
    CG11534-PA
    DEF8-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12132146..12133834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140292.3 → NP_648549.1  differentially expressed in FDCP 8 homolog [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648549.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VTT9
      Related
      FBpp0075727
      Conserved Domains (2) summary
      smart00109
      Location:173 → 214
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      pfam13901
      Location:259 → 461
      zf-RING_9; Putative zinc-RING and/or ribbon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTT9.1 Q9VTT9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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