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    Mtpalpha Mitochondrial trifunctional protein alpha subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34276, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtpalphaprovided by FlyBase
    Official Full Name
    Mitochondrial trifunctional protein alpha subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028479
    Locus tag
    Dmel_CG4389
    See related
    AllianceGenome:FB:FBgn0028479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH12558; CG 4389; CG4389; Dmel\CG4389; Hadha; HADHA; LBP; Mtp alpha
    Summary
    Predicted to enable enoyl-CoA hydratase activity and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Involved in determination of adult lifespan; fatty acid beta-oxidation; and response to starvation. Located in peroxisome. Is expressed in adult head; adult heart; embryonic/larval lymph gland; organism; and spermatozoon. Used to study lipid metabolism disorder and steatotic liver disease. Human ortholog(s) of this gene implicated in mitochondrial trifunctional protein deficiency and steatotic liver disease. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mtpalpha in Genome Data Viewer
    Location:
    30B12-30B12; 2-35 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9573563..9576769, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9573563..9576769, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene junctophilin Neighboring gene long non-coding RNA:CR44149 Neighboring gene brickwall Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43621 Neighboring gene glial cells missing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impaired fatty acid oxidation in a Drosophila model of mitochondrial trifunctional protein (MTP) deficiency. Kishita Y, et al. Biochem Biophys Res Commun, 2012 Mar 9. PMID 22342726
    2. Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Katewa SD, et al. Cell Metab, 2012 Jul 3. PMID 22768842, Free PMC Article
    3. Comparison of cardiolipins from Drosophila strains with mutations in putative remodeling enzymes. Schlame M, et al. Chem Phys Lipids, 2012 Jul. PMID 22465155
    4. Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo. Llavero Hurtado M, et al. Sci Rep, 2017 Sep 29. PMID 28963550, Free PMC Article
    5. Pre-adult exposure to three heavy metals leads to changes in the head transcriptome of adult flies. Felmlee KR, et al. MicroPubl Biol, 2022. PMID 35856016, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enoyl-CoA hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enoyl-CoA hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enoyl-CoA hydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing HMP PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial fatty acid beta-oxidation multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial fatty acid beta-oxidation multienzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial trifunctional protein alpha subunit
    Names
    CG4389-PA
    CG4389-PB
    Mtpalpha-PA
    Mtpalpha-PB
    NP_609299.1
    NP_723470.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9573563..9576769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164860.2 → NP_723470.1  mitochondrial trifunctional protein alpha subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723470.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPE8
      Related
      FBpp0079453
      Conserved Domains (4) summary
      cd06558
      Location:13 → 196
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
      TIGR02441
      Location:1 → 736
      fa_ox_alpha_mit; fatty acid oxidation complex, alpha subunit, mitochondrial
      pfam00725
      Location:517 → 612
      3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
      pfam02737
      Location:336 → 514
      3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

    2. NM_135455.3 → NP_609299.1  mitochondrial trifunctional protein alpha subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609299.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V397
      Related
      FBpp0079454
      Conserved Domains (4) summary
      cd06558
      Location:52 → 235
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
      TIGR02441
      Location:38 → 775
      fa_ox_alpha_mit; fatty acid oxidation complex, alpha subunit, mitochondrial
      pfam00725
      Location:556 → 651
      3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
      pfam02737
      Location:375 → 553
      3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IPE8 Q8IPE8
    Q9V397 Q9V397

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