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    P5CS Delta[1]-pyrroline-5-carboxylate synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40443, updated on 27-Dec-2024

    Summary

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    Official Symbol
    P5CSprovided by FlyBase
    Official Full Name
    Delta[1]-pyrroline-5-carboxylate synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037146
    Locus tag
    Dmel_CG7470
    See related
    AllianceGenome:FB:FBgn0037146
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7470; Dmel\CG7470; dP5CS
    Summary
    Enables glutamate 5-kinase activity and glutamate-5-semialdehyde dehydrogenase activity. Predicted to be involved in proline biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrial matrix. Is expressed in adult head; adult heart; embryonic/larval fat body; embryonic/larval midgut; and yolk nucleus. Used to study amino acid metabolic disorder. Human ortholog(s) of this gene implicated in cataract; cutis laxa (multiple); enterocele; and hereditary spastic paraplegia (multiple). Orthologous to human ALDH18A1 (aldehyde dehydrogenase 18 family member A1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See P5CS in Genome Data Viewer
    Location:
    79A5-79A6; 3-47 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21972002..21984606)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21965102..21977706)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45757 Neighboring gene Chitin synthase 2 Neighboring gene Actin 79B Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis of dynamic P5CS filaments. Zhong J, et al. Elife, 2022 Mar 14. PMID 35286254, Free PMC Article
    2. Pyrroline-5-carboxylate synthase senses cellular stress and modulates metabolism by regulating mitochondrial respiration. Yang Z, et al. Cell Death Differ, 2021 Jan. PMID 32770108, Free PMC Article
    3. The proline synthesis enzyme P5CS forms cytoophidia in Drosophila. Zhang B, et al. J Genet Genomics, 2020 Mar 20. PMID 32317150
    4. Nutrition controls mitochondrial biogenesis in the Drosophila adipose tissue through Delg and cyclin D/Cdk4. Baltzer C, et al. PLoS One, 2009 Sep 9. PMID 19742324, Free PMC Article
    5. Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. O'Keefe LV, et al. Hum Mol Genet, 2011 Feb 1. PMID 21075834, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate-5-semialdehyde dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate-5-semialdehyde dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate-5-semialdehyde dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate-5-semialdehyde dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Delta[1]-pyrroline-5-carboxylate synthase
    Names
    CG7470-PA
    CG7470-PB
    P5CS-PA
    P5CS-PB
    glutamate 5-kinase
    NP_001246877.1
    NP_649375.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21972002..21984606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259948.2 → NP_001246877.1  Delta[1]-pyrroline-5-carboxylate synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246877.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNW6
      Conserved Domains (3) summary
      TIGR01092
      Location:50 → 775
      P5CS; delta l-pyrroline-5-carboxylate synthetase
      cd07079
      Location:349 → 753
      ALDH_F18-19_ProA-GPR; Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19
      cd04256
      Location:49 → 337
      AAK_P5CS_ProBA; AAK_P5CS_ProBA: Glutamate-5-kinase (G5K) domain of the bifunctional delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR, ProA), the first and second enzyme ...

    2. NM_141118.5 → NP_649375.1  Delta[1]-pyrroline-5-carboxylate synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649375.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNW6
      Related
      FBpp0078130
      Conserved Domains (3) summary
      TIGR01092
      Location:50 → 775
      P5CS; delta l-pyrroline-5-carboxylate synthetase
      cd07079
      Location:349 → 753
      ALDH_F18-19_ProA-GPR; Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19
      cd04256
      Location:49 → 337
      AAK_P5CS_ProBA; AAK_P5CS_ProBA: Glutamate-5-kinase (G5K) domain of the bifunctional delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR, ProA), the first and second enzyme ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNW6 Q9VNW6

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