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    CG42542 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 8674000, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42542provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260659
    Locus tag
    Dmel_CG42542
    See related
    AllianceGenome:FB:FBgn0260659
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31303; CG4196; Dmel\CG42542
    Old locus tag
    Dmel_CG31303; Dmel_CG4196
    Summary
    Predicted to enable calcium ion transmembrane transporter activity and manganese ion transmembrane transporter activity. Predicted to be involved in Golgi calcium ion homeostasis and metal ion transport. Predicted to be active in Golgi apparatus. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIk. Orthologous to human TMEM165 (transmembrane protein 165). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42542 in Genome Data Viewer
    Location:
    88E2-88E3; 3-56 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15196598..15203074)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11022320..11028796)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Guanylyl cyclase at 88E Neighboring gene Myofilin Neighboring gene mir-3644 stem loop Neighboring gene Kip1 ubiquitination-promoting complex subunit 1 Neighboring gene Serpin 88Ea Neighboring gene Serpin 88Eb Neighboring gene Mau2 sister chromatid cohesion factor Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Identification and Evolutionary Trends of the Solute Carrier Superfamily in Arthropods. Denecke SM, et al. Genome Biol Evol, 2020 Aug 1. PMID 32681801, Free PMC Article
    2. Iap2 is required for a sustained response in the Drosophila Imd pathway. Valanne S, et al. Dev Comp Immunol, 2007. PMID 17343912
    3. Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration. Nelson B, et al. Cell Death Differ, 2005 Aug. PMID 15861189
    4. The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster. Zhou S, et al. Environ Health Perspect, 2016 Jul. PMID 26859824, Free PMC Article
    5. A genetic interaction map of cell cycle regulators. Billmann M, et al. Mol Biol Cell, 2016 Apr 15. PMID 26912791, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables manganese ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi calcium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in manganese ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42542-PB
    CG42542-PC
    CG42542-PD
    CG42542-PE
    CG42542-PF
    CG42542-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15196598..15203074
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170143.2 → NP_001163614.1  uncharacterized protein Dmel_CG42542, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIL1
      Conserved Domains (2) summary
      COG2119
      Location:97 → 183
      Gdt1; Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only]
      pfam01169
      Location:423 → 492
      UPF0016; Uncharacterized protein family UPF0016

    2. NM_142169.4 → NP_650426.1  uncharacterized protein Dmel_CG42542, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650426.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVE8, Q7KSI9
      Conserved Domains (1) summary
      COG2119
      Location:97 → 316
      Gdt1; Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only]

    3. NM_001170145.2 → NP_001163616.1  uncharacterized protein Dmel_CG42542, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163616.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVE8, Q7KSI9
      Conserved Domains (1) summary
      COG2119
      Location:97 → 316
      Gdt1; Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only]

    4. NM_001170144.2 → NP_001163615.1  uncharacterized protein Dmel_CG42542, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163615.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIL1
      Conserved Domains (2) summary
      COG2119
      Location:97 → 183
      Gdt1; Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only]
      pfam01169
      Location:423 → 492
      UPF0016; Uncharacterized protein family UPF0016

    5. NM_170649.2 → NP_731978.1  uncharacterized protein Dmel_CG42542, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731978.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVE8, Q7KSI9
      Conserved Domains (1) summary
      COG2119
      Location:97 → 316
      Gdt1; Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only]

    6. NM_169620.2 → NP_731979.2  uncharacterized protein Dmel_CG42542, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731979.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5WLL7, Q8INE9
      Conserved Domains (2) summary
      COG2119
      Location:226 → 306
      Gdt1; Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only]
      pfam01169
      Location:233 → 302
      UPF0016; Uncharacterized protein family UPF0016
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIL1 E1JIL1
    Q7KSI9 Q7KSI9
    Q8INE9 Q8INE9

    Gene LinkOut

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