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    GstT4 Glutathione S transferase T4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32299, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GstT4provided by FlyBase
    Official Full Name
    Glutathione S transferase T4provided by FlyBase
    Primary source
    FLYBASE:FBgn0030484
    Locus tag
    Dmel_CG1681
    See related
    AllianceGenome:FB:FBgn0030484
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1681; dGSTT4; Dmel\CG1681; DmGSTT4; GST-theta; gstt4; GSTT4
    Summary
    Predicted to enable glutathione peroxidase activity. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and yolk nucleus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cancer (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including GSTT1 (glutathione S-transferase theta 1); GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene)); and GSTT2B (glutathione S-transferase theta 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstT4 in Genome Data Viewer
    Location:
    11F4-11F4; 1-43 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13404749..13409323)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13298782..13303356)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Branched chain amino acid transaminase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SET domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combination of hypomorphic mutations of the Drosophila homologues of aryl hydrocarbon receptor and nucleosome assembly protein family genes disrupts morphogenesis, memory and detoxification. Kuzin BA, et al. PLoS One, 2014. PMID 24736732, Free PMC Article
    2. Using Drosophila melanogaster to identify chemotherapy toxicity genes. King EG, et al. Genetics, 2014 Sep. PMID 25236447, Free PMC Article
    3. Drosophila embryos allocate lipid droplets to specific lineages to ensure punctual development and redox homeostasis. Kilwein MD, et al. PLoS Genet, 2023 Aug. PMID 37578970, Free PMC Article
    4. Interaction of Omega, Sigma, and Theta glutathione transferases with p38b mitogen-activated protein kinase from the fruit fly, Drosophila melanogaster. Wongtrakul J, et al. J Insect Sci, 2014 May 1. PMID 25373207, Free PMC Article
    5. Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers. Akishina AA, et al. Oncotarget, 2017 Nov 28. PMID 29262535, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase T4
    Names
    CG1681-PA
    GstT4-PA
    NP_572886.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13404749..13409323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132658.2 → NP_572886.2  glutathione S transferase T4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572886.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F6J6F4, Q8MRM0, Q9VYD3
      Related
      FBpp0073609
      Conserved Domains (2) summary
      cd03183
      Location:95 → 220
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      cd03050
      Location:5 → 80
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRM0 Q8MRM0

    Gene LinkOut

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