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    Drice Death related ICE-like caspase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Driceprovided by FlyBase
    Official Full Name
    Death related ICE-like caspaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0019972
    Locus tag
    Dmel_CG7788
    See related
    AllianceGenome:FB:FBgn0019972
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    caspase 3; CG7788; crice; Dmel\CG7788; drice; drIce; drICE; DriCE; DrIce; DrICE; DRICE; Drive; ice; Ice; ICE
    Summary
    Enables BIR domain binding activity; cysteine-type endopeptidase activity involved in execution phase of apoptosis; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of signal transduction; neuron remodeling; and nurse cell apoptotic process. Located in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including central brain primordium; cystic bulge; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. Human ortholog(s) of this gene implicated in breast cancer; gastrointestinal system cancer (multiple); lung non-small cell carcinoma; and neurodegenerative disease (multiple). Orthologous to human CASP3 (caspase 3) and CASP7 (caspase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Drice in Genome Data Viewer
    Location:
    99C1-99C1; 3-99 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29799658..29801584)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25625380..25627306)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene kayak Neighboring gene fos intronic gene Neighboring gene shroud Neighboring gene R and B Neighboring gene Electron transfer flavoprotein beta subunit Neighboring gene uncharacterized protein Neighboring gene non-claret disjunctional

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a Drosophila melanogaster ICE/CED-3-related protease, drICE. Fraser AG, et al. EMBO J, 1997 May 15. PMID 9184225, Free PMC Article
    2. Crucial Roles of Ubiquitin Carboxy-Terminal Hydrolase L1 in Motor Neuronal Health by Drosophila Model. Huynh TKT, et al. Antioxid Redox Signal, 2022 Aug. PMID 35343238
    3. aza-Flavanones as potent cross-species microRNA inhibitors that arrest cell cycle. Chandrasekhar S, et al. Bioorg Med Chem Lett, 2012 Jan 1. PMID 22100313
    4. Active depletion of host cell inhibitor-of-apoptosis proteins triggers apoptosis upon baculovirus DNA replication. Vandergaast R, et al. J Virol, 2011 Aug. PMID 21653668, Free PMC Article
    5. The role of the effector caspases drICE and dcp-1 for cell death and corpse clearance in the developing optic lobe in Drosophila. Akagawa H, et al. Dev Biol, 2015 Aug 15. PMID 26022392

    See all (387) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila.
      Title: Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila.
    2. drICE plays an important role in activating corpse clearance in dying cells, and that an additional function of effector caspases is required for the activation of corpse clearance as well as that for carrying out cell death.
      Title: The role of the effector caspases drICE and dcp-1 for cell death and corpse clearance in the developing optic lobe in Drosophila.
    3. Both autophagy and caspase activity are induced by 20-hydroxyecdysone during the larval-prepupal transition.
      Title: Balancing crosstalk between 20-hydroxyecdysone-induced autophagy and caspase activity in the fat body during Drosophila larval-prepupal transition.
    4. The cleaved DIAP1 binds drICE, inhibits its protease activity, and also targets drICE for ubiquitylation.
      Title: Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE.
    5. Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1, and ice
      Title: Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis.
    6. Data suggest that the cleaved-Caspase-3 antibody recognizes multiple proteins including DCP-1 and likely DRICE, but also at least one additional unknown protein, all of which require DRONC for epitope exposure.
      Title: The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila.
    7. sterol regulatory element-binding protein is activated by the caspase Drice in Drosophila larvae
      Title: Activation of sterol regulatory element-binding protein by the caspase Drice in Drosophila larvae.
    8. Arm is a major regulator of cadherin-mediated adhesion and is cleaved by caspases in embryo extracts and study provides evidence that the caspase-3 homolog drICE cleaves Arm in vitro and in vivo.
      Title: Cleavage of Armadillo/beta-catenin by the caspase DrICE in Drosophila apoptotic epithelial cells.
    9. The conjugation of ubiquitin to ice suppresses its catalytic potential in cleaving caspase substrates.
      Title: Inactivation of effector caspases through nondegradative polyubiquitylation.
    10. Because DIAP2 efficiently interacts with drICE, our data suggest that DIAP2 controls drICE in its apoptotic and nonapoptotic roles.
      Title: DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables BIR domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in compound eye retinal cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in execution phase of apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Toll signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nurse cell apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in programmed cell death IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in programmed cell death involved in cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to X-ray IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in salivary gland histolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    death related ICE-like caspase
    Names
    CG7788-PA
    Drice-PA
    Ice
    caspase 3
    caspase-3
    drice
    interleukin-1beta-converting enzyme
    NP_524551.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29799658..29801584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079827.3 → NP_524551.2  death related ICE-like caspase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524551.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01382, Q9VAH1
      Related
      FBpp0084848
      Conserved Domains (1) summary
      smart00115
      Location:86 → 330
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01382.2 O01382

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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