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    Sidpn similar to Deadpan [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35168, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sidpnprovided by FlyBase
    Official Full Name
    similar to Deadpanprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032741
    Locus tag
    Dmel_CG10446
    See related
    AllianceGenome:FB:FBgn0032741
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bHLHe51; CG10446; Dmel\CG10446; side; Side
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; eye; ganglia; larval nervous system; and spermatozoon. Orthologous to several human genes including BHLHE40 (basic helix-loop-helix family member e40); BHLHE41 (basic helix-loop-helix family member e41); and HES3 (hes family bHLH transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sidpn in Genome Data Viewer
    Location:
    37B9-37B10; 2-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19027710..19030780)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19027710..19030780)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43700 Neighboring gene uncharacterized protein Neighboring gene hook Neighboring gene uncharacterized protein Neighboring gene mind bomb 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maternal Groucho and bHLH repressors amplify the dose-sensitive X chromosome signal in Drosophila sex determination. Lu H, et al. Dev Biol, 2008 Nov 15. PMID 18773886, Free PMC Article
    2. The MTE, a new core promoter element for transcription by RNA polymerase II. Lim CY, et al. Genes Dev, 2004 Jul 1. PMID 15231738, Free PMC Article
    3. A genomewide survey of basic helix-loop-helix factors in Drosophila. Moore AW, et al. Proc Natl Acad Sci U S A, 2000 Sep 12. PMID 10973473, Free PMC Article
    4. Dynamics of Gene Co-expression Networks in Time-Series Data: A Case Study in Drosophila melanogaster Embryogenesis. Lau LY, et al. Front Genet, 2020. PMID 32528531, Free PMC Article
    5. The two Tribolium E(spl) genes show evolutionarily conserved expression and function during embryonic neurogenesis. Kux K, et al. Mech Dev, 2013 Apr-May. PMID 23485410

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Beat-Sidestep interaction network provides insights into Drosophila neuromuscular system development.
      Title: Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_523599.1
    • similar to deadpan

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19027710..19030780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078875.3 → NP_523599.1  uncharacterized protein Dmel_CG10446 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523599.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJ16
      Related
      FBpp0080685
      Conserved Domains (2) summary
      cd00083
      Location:48 → 117
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam07527
      Location:125 → 172
      Hairy_orange; Hairy Orange
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJ16 Q9VJ16

    Gene LinkOut

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