Zmynd8 Zinc finger MYND-type containing 8 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Zmynd8provided by FlyBase
Official Full Name: Zinc finger MYND-type containing 8provided by FlyBase
Primary source: FLYBASE:FBgn0039863
Locus tag: Dmel_CG1815
See related: AllianceGenome:FB:FBgn0039863
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cg1815; CG1815; Dmel\CG1815
Summary: Predicted to enable lysine-acetylated histone binding activity; methylated histone binding activity; and transcription corepressor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including anlage in statu nascendi; dorsal ectoderm; hindgut anlage; inclusive hindgut primordium; and somatic muscle primordium. Used to study syndromic intellectual disability. Orthologous to human ZMYND8 (zinc finger MYND-type containing 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 100D1-100D1; 3-102 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (31669465..31677971)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (27495187..27503693)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables lysine-acetylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables methylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger MYND-type containing 8

Names: CG1815-PB; CG1815-PC; Zmynd8-PB; Zmynd8-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

31669465..31677971

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143624.3 → NP_651881.2 zinc finger MYND-type containing 8, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651881.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KRS9, Q8IMG3

Related

FBpp0085185

Conserved Domains (5) summary

cd05841
Location:520 → 603

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:403 → 501

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:345 → 386

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:1399 → 1433

zf-MYND; MYND finger

pfam11593
Location:1428 → 1664

Med3; Mediator complex subunit 3 fungal
NM_170563.2 → NP_733442.1 zinc finger MYND-type containing 8, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733442.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T9C8

Related

FBpp0085184

Conserved Domains (3) summary

cd15538
Location:345 → 386

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

cl02554
Location:520 → 603

PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

cl02556
Location:403 → 501

Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.