14-3-3zeta 14-3-3zeta [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: 14-3-3zetaprovided by FlyBase
Official Full Name: 14-3-3zetaprovided by FlyBase
Primary source: FLYBASE:FBgn0004907
Locus tag: Dmel_CG17870
See related: AllianceGenome:FB:FBgn0004907
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 14-3-3; 14-3-3 zeta; 14-3-3-Leo; 14-3-3-zeta; 14-3-3leo; 14-3-3z; 14-3-3ZETA; 14.3.3; 1433Z; 2G1; 4-3-3 zeta; 5.11; 549; BEST:GH05075; CG17870; D14-3-3; d14-3-3zeta; D14-3-3zeta; Dmel\CG17870; K; l(2)07103; l(2)46CFe; l(2)46Ee; leo; Leo; LEO; par-5; Par-5; PAR-5; PAR5
Summary: Enables molecular sequestering activity; protein dimerization activity; and transcription coactivator binding activity. Involved in several processes, including oocyte differentiation; positive regulation of signal transduction; and protein stabilization. Located in germline ring canal. Is expressed in several structures, including ganglia; gut section; imaginal disc; neuromuscular junction; and synaptic neuropil domain. Used to study intellectual disability. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to several human genes including YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta) and YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 46E6-46E8; 2-62 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (10099677..10109687)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5987182..5997192)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The adaptor protein 14-3-3zeta modulates intestinal immunity and aging in Drosophila.
Title: The adaptor protein 14-3-3zeta modulates intestinal immunity and aging in Drosophila.
Our collective data demonstrate the complexity of 14-3-3/Tau interactions in vivo and suggest that 14-3-3 attenuation is not appropriate ameliorative treatment of Tauopathies. Finally, we suggest that 'bystander' 14-3-3s are recruited by accumulating Tau with the consequences depending on the composition of available dimers within particular neurons and the Tau variant.
Title: Differential effects of 14-3-3 dimers on Tau phosphorylation, stability and toxicity in vivo.
Study suggests a novel mechanism of Tor regulation mediated by 14-3-3 interaction with Tctp and Rheb.
Title: 14-3-3 proteins regulate Tctp-Rheb interaction for organ growth in Drosophila.
The Khc73 stalk/14-3-3/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.
Title: A NudE/14-3-3 pathway coordinates dynein and the kinesin Khc73 to position the mitotic spindle.
Hpo signaling inhibited Yki nuclear localization and activity by phosphorylating Yki and both isoforms of 14-3-3, 14-3-3varepsilon and 14-3-3zeta, regulate Yki activity through modulating its subcellular localization.
Title: Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms.
in vivo 14-3-3zeta monomer properties and functionality
Title: Dimerization is essential for 14-3-3zeta stability and function in vivo.
Results report a bona fide third functional isoform encoded by leo divergent from the other two in structurally and functionally significant areas.
Title: A third functional isoform enriched in mushroom body neurons is encoded by the Drosophila 14-3-3zeta gene.
monomeric D14-3-3zeta is capable of modulating dSlo channel activity in this regulatory complex.
Title: Monomeric 14-3-3 protein is sufficient to modulate the activity of the Drosophila slowpoke calcium-dependent potassium channel.
These observations provide the first direct evidence that a 14-3-3 protein functions as a stress-induced molecular chaperone that dissolves and renaturalizes thermal-aggregated proteins.
Title: A novel function of 14-3-3 protein: 14-3-3zeta is a heat-shock-related molecular chaperone that dissolves thermal-aggregated proteins.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables molecular sequestering activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in R8 cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic sequestering of protein	IDA Inferred from Direct Assay more info	PubMed
involved_in germarium-derived oocyte fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle, embryonic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte microtubule cytoskeleton polarization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of Ras protein signal transduction	HGI more info	PubMed
involved_in positive regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of torso signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in protein folding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in germline ring canal	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: 14-3-3zeta

Names: 14-3-3zeta-PA; 14-3-3zeta-PB; 14-3-3zeta-PC; 14-3-3zeta-PD; 14-3-3zeta-PE; 14-3-3zeta-PF; 14-3-3zeta-PG; 14-3-3zeta-PH; 14-3-3zeta-PI; 14-3-3zeta-PJ; 14-3-3zeta-PK; 14-3-3zeta-PL; CG17870-PA; CG17870-PB; CG17870-PC; CG17870-PD; CG17870-PE; CG17870-PF; CG17870-PG; CG17870-PH; CG17870-PI; CG17870-PJ; CG17870-PK; CG17870-PL; D14 3 3 protein; Leonardo-13-3-3; complementation group K; leonardo; leonardo 14-3-3