dob doppelganger von brummer [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dobprovided by FlyBase
Official Full Name: doppelganger von brummerprovided by FlyBase
Primary source: FLYBASE:FBgn0030607
Locus tag: Dmel_CG5560
See related: AllianceGenome:FB:FBgn0030607
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5560; Dmel\CG5560; Dob
Summary: Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid homeostasis and triglyceride catabolic process. Predicted to be active in cytoplasm; lipid droplet; and membrane. Is expressed in organism. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 10; coronary artery disease; liver disease (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including PNPLA2 (patatin like phospholipase domain containing 2); PNPLA3 (patatin like phospholipase domain containing 3); and PNPLA5 (patatin like phospholipase domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (15067007..15069091)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (14961040..14963124)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables triacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triacylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

NP_572995.1

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The following sections contain reference sequences that belong to a specific genome build. Explain