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    Rcd1 Reduction in Cnn dots 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36560, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rcd1provided by FlyBase
    Official Full Name
    Reduction in Cnn dots 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033897
    Locus tag
    Dmel_CG8233
    See related
    AllianceGenome:FB:FBgn0033897
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg8233; CG8233; Dmel\CG8233; Nsl3; NSL3
    Summary
    Predicted to enable hydrolase activity. Involved in centriole replication and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of NSL complex. Is expressed in adult head and organism. Orthologous to human KANSL3 (KAT8 regulatory NSL complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rcd1 in Genome Data Viewer
    Location:
    50E1-50E1; 2-69 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14148263..14153123, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10035768..10040628, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene prosap Neighboring gene uncharacterized protein Neighboring gene mir-989 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene peanuts Neighboring gene Cysteinyl-tRNA synthetase, mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation. Gaub A, et al. Nat Commun, 2020 May 7. PMID 32382029, Free PMC Article
    2. The NSL complex regulates housekeeping genes in Drosophila. Lam KC, et al. PLoS Genet, 2012. PMID 22723752, Free PMC Article
    3. An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis. Meunier S, et al. Nat Commun, 2015 Aug 5. PMID 26243146, Free PMC Article
    4. RNAi-mediated depletion of the NSL complex subunits leads to abnormal chromosome segregation and defective centrosome duplication in Drosophila mitosis. Pavlova GA, et al. PLoS Genet, 2019 Sep. PMID 31527906, Free PMC Article
    5. Scrutinizing the human TEX genes in the context of human male infertility. Sieper MH, et al. Andrology, 2024 Mar. PMID 37594251

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NSL complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    reduction in Cnn dots 1
    Names
    CG8233-PA
    CG8233-PB
    CG8233-PC
    CG8233-PD
    CG8233-PE
    CG8233-PF
    CG8233-PG
    CG8233-PH
    Rcd1-PA
    Rcd1-PB
    Rcd1-PC
    Rcd1-PD
    Rcd1-PE
    Rcd1-PF
    Rcd1-PG
    Rcd1-PH
    non-specific lethal 3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14148263..14153123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166031.3 → NP_725357.2  reduction in Cnn dots 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725357.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9L0
      Related
      FBpp0086708

    2. NM_001274035.2 → NP_001260964.1  reduction in Cnn dots 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260964.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFX4

    3. NM_001274033.2 → NP_001260962.1  reduction in Cnn dots 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260962.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEP1

    4. NM_166032.3 → NP_725358.1  reduction in Cnn dots 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725358.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9L2
      Related
      FBpp0086710

    5. NM_137083.4 → NP_610927.3  reduction in Cnn dots 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610927.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T076
      Related
      FBpp0086709

    6. NM_001274036.2 → NP_001260965.1  reduction in Cnn dots 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260965.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFM5

    7. NM_001299475.1 → NP_001286404.1  reduction in Cnn dots 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286404.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFC1

    8. NM_001274034.2 → NP_001260963.1  reduction in Cnn dots 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260963.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF25
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEP1 A0A0B4KEP1
    A0A0B4KF25 A0A0B4KF25
    A0A0B4KFM5 A0A0B4KFM5
    A0A0B4KFX4 A0A0B4KFX4
    A0A0B4LFC1 A0A0B4LFC1
    A1Z9L0 A1Z9L0
    A1Z9L2 A1Z9L2
    Q8T076 Q8T076

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