MAN1 MAN1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: MAN1provided by FlyBase
Official Full Name: MAN1provided by FlyBase
Primary source: FLYBASE:FBgn0034962
Locus tag: Dmel_CG3167
See related: AllianceGenome:FB:FBgn0034962
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD24895; CG3167; dMan1; dMAN1; Dmel\CG3167
Summary: Predicted to enable chromatin DNA binding activity. Involved in negative regulation of BMP signaling pathway. Located in endomembrane system. Is expressed in adult head; organism; wing hinge primordium; and wing pouch. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome and cataract 46 juvenile-onset. Orthologous to several human genes including LEMD3 (LEM domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 60B5-60B5; 2-106 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24033974..24036707)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19921497..19924230)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAN1 negatively regulates accumulation and distribution of bone morphogenetic protein signaling.
Title: MAN1 Restricts BMP Signaling During Synaptic Growth in Drosophila.
neither Bocks nor Ote rescued dMAN1-/- mutant phenotypes, implying that dMAN1 makes unique contributions to wing development
Title: Unique and shared functions of nuclear lamina LEM domain proteins in Drosophila.
Genetic interaction experiments suggest that MAN1 is a BMP signaling antagonist both at the neuromuscular junction and during crossvein formation
Title: The Drosophila LEM-domain protein MAN1 antagonizes BMP signaling at the neuromuscular junction and the wing crossveins.
Tissue-specific defects are caused by loss of the Drosophila MAN1 LEM domain protein
Title: Tissue-specific defects are caused by loss of the Drosophila MAN1 LEM domain protein.
description of the Drosophila melanogaster LEM-domain protein encoded by the gene CG3167 which is the putative ortholog to vertebrate MAN1; concluded that MAN1 protein is not a limiting component of the nuclear architecture in Drosophila cultured cells
Title: The Drosophila melanogaster LEM-domain protein MAN1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear envelope organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endomembrane system	HDA more info	PubMed

General protein information

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Preferred Names: MAN1

Names: CG3167-PA; CG3167-PB; CG3167-PC; MAN1-PA; MAN1-PB; MAN1-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

24033974..24036707

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299883.1 → NP_001286812.1 MAN1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286812.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7JRE4, Q961B2

Conserved Domains (3) summary

smart00540
Location:4 → 47

LEM; in nuclear membrane-associated proteins

cd12286
Location:542 → 631

RRM_Man1; RNA recognition motif in inner nuclear membrane protein Man1 (Man1) and similar proteins

pfam09402
Location:381 → 509

MSC; Man1-Src1p-C-terminal domain
NM_166651.2 → NP_726404.1 MAN1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726404.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7JRE4, Q961B2

Related

FBpp0072075

Conserved Domains (3) summary

smart00540
Location:4 → 47

LEM; in nuclear membrane-associated proteins

cd12286
Location:542 → 631

RRM_Man1; RNA recognition motif in inner nuclear membrane protein Man1 (Man1) and similar proteins

pfam09402
Location:381 → 509

MSC; Man1-Src1p-C-terminal domain
NM_138029.3 → NP_611873.1 MAN1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611873.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7JRE4, Q961B2

Related

FBpp0072076

Conserved Domains (3) summary

smart00540
Location:4 → 47

LEM; in nuclear membrane-associated proteins

cd12286
Location:542 → 631

RRM_Man1; RNA recognition motif in inner nuclear membrane protein Man1 (Man1) and similar proteins

pfam09402
Location:381 → 509

MSC; Man1-Src1p-C-terminal domain