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    l(2)05287 lethal (2) 05287 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35374, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(2)05287provided by FlyBase
    Official Full Name
    lethal (2) 05287provided by FlyBase
    Primary source
    FLYBASE:FBgn0284251
    Locus tag
    Dmel_CG12050
    See related
    AllianceGenome:FB:FBgn0284251
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12050; Dmel\CG12050
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; larval muscle cell; and mesoderm. Orthologous to human WDR75 (WD repeat domain 75). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(2)05287 in Genome Data Viewer
    Location:
    39A1-39A2; 2-54 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21094966..21102429, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21094966..21102429, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43809 Neighboring gene long non-coding RNA:CR44056 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Na[+]/H[+] hydrogen exchanger 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear genomic control of naturally occurring variation in mitochondrial function in Drosophila melanogaster. Jumbo-Lucioni P, et al. BMC Genomics, 2012 Nov 22. PMID 23171078, Free PMC Article
    2. Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth. Marie B, et al. Neuron, 2004 Jul 22. PMID 15260957
    3. Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis. Koh TW, et al. Neuron, 2004 Jul 22. PMID 15260956
    4. Selective sweep analysis in the genomes of the 91-R and 91-C Drosophila melanogaster strains reveals few of the 'usual suspects' in dichlorodiphenyltrichloroethane (DDT) resistance. Steele LD, et al. PLoS One, 2015. PMID 25826265, Free PMC Article
    5. A Genetic Mosaic Screen Reveals Ecdysone-Responsive Genes Regulating Drosophila Oogenesis. Ables ET, et al. G3 (Bethesda), 2016 Aug 9. PMID 27226164, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lethal (2) 05287
    Names
    CG12050-PB
    l(2)05287-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21094966..21102429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136242.4 → NP_610086.3  lethal (2) 05287 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610086.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RG7, Q9VIG1
      Conserved Domains (3) summary
      COG2319
      Location:26 → 324
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:205 → 244
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:245 → 544
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95RG7 Q95RG7
    Q9VIG1 Q9VIG1

    Gene LinkOut

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