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    Atu Another transcription unit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40684, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atuprovided by FlyBase
    Official Full Name
    Another transcription unitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0019637
    Locus tag
    Dmel_CG1433
    See related
    AllianceGenome:FB:FBgn0019637
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    atu; CG1433; dLeo1; Dmel\CG1433; l(3)s1938; Leo1
    Summary
    Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in regulation of hemocyte proliferation. Predicted to be part of Cdc73/Paf1 complex. Predicted to be active in nucleus. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm. Orthologous to human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Atu in Genome Data Viewer
    Location:
    83B6-83B6; 3-47.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5613358..5615939)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1439080..1441661)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene asterless Neighboring gene Antisense transcript of Rga Neighboring gene Regena Neighboring gene stable intronic sequence RNA 1 Neighboring gene antisense RNA:CR46135 Neighboring gene Spec2 Neighboring gene ncRNA Neighboring gene Diphthamide biosynthesis 4 Neighboring gene Ribosomal protein L13A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of the Paf1 complex in the maintenance of stem cell pluripotency and development. Park J, et al. FEBS J, 2023 Feb. PMID 35869661
    2. Parafibromin governs cell polarity and centrosome assembly in Drosophila neural stem cells. Deng Q, et al. PLoS Biol, 2022 Oct. PMID 36223339, Free PMC Article
    3. PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters. Gerlach JM, et al. Proc Natl Acad Sci U S A, 2017 Oct 31. PMID 29078288, Free PMC Article
    4. Regena (Rga), a Drosophila homolog of the global negative transcriptional regulator CDC36 (NOT2) from yeast, modifies gene expression and suppresses position effect variegation. Frolov MV, et al. Genetics, 1998 Jan. PMID 9475742, Free PMC Article
    5. Cytoplasmic polyadenylation element binding protein is a conserved target of tumor suppressor HRPT2/CDC73. Zhang JH, et al. Cell Death Differ, 2010 Oct. PMID 20339377, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA polymerase II C-terminal domain phosphoserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of hemocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cdc73/Paf1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    another transcription unit
    Names
    Atu-PA
    CG1433-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5613358..5615939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079516.3 → NP_524240.1  another transcription unit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524240.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94546, Q9VNE6
      Related
      FBpp0078353
      Conserved Domains (1) summary
      pfam04004
      Location:396 → 550
      Leo1; Leo1-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94546.2 Q94546

    Gene LinkOut

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