U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Oatp33Ea Organic anion transporting polypeptide 33Ea [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34660, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Oatp33Eaprovided by FlyBase
    Official Full Name
    Organic anion transporting polypeptide 33Eaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032433
    Locus tag
    Dmel_CG5427
    See related
    AllianceGenome:FB:FBgn0032433
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5427; Dmel\CG5427; EcI-2; oatp 33Ea
    Summary
    Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport and transmembrane transport. Located in intracellular membrane-bounded organelle. Is expressed in adult head. Orthologous to human SLCO2B1 (solute carrier organic anion transporter family member 2B1) and SLCO3A1 (solute carrier organic anion transporter family member 3A1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Oatp33Ea in Genome Data Viewer
    Location:
    33E5-33E5; 2-46 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12441401..12445924, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12441401..12445924, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SR family splicing factor SC35 Neighboring gene eukaryotic translation release factor 3 Neighboring gene uncharacterized protein Neighboring gene Organic anion transporting polypeptide 33Eb Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Essential functions of mosquito ecdysone importers in development and reproduction. Hun LV, et al. Proc Natl Acad Sci U S A, 2022 Jun 21. PMID 35696563, Free PMC Article
    2. Resolution of the insect ouabain paradox. Torrie LS, et al. Proc Natl Acad Sci U S A, 2004 Sep 14. PMID 15347816, Free PMC Article
    3. An Oatp transporter-mediated steroid sink promotes tumor-induced cachexia in Drosophila. Santabárbara-Ruiz P, et al. Dev Cell, 2021 Oct 11. PMID 34610327
    4. Barrier mechanisms in the Drosophila blood-brain barrier. Hindle SJ, et al. Front Neurosci, 2014. PMID 25565944, Free PMC Article
    5. A Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila. Okamoto N, et al. Dev Cell, 2018 Nov 5. PMID 30293839, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic anion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in intracellular organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    organic anion transporting polypeptide 33Ea
    Names
    CG5427-PA
    CG5427-PB
    Oatp33Ea-PA
    Oatp33Ea-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12441401..12445924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273488.1 → NP_001260417.1  organic anion transporting polypeptide 33Ea, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260417.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK84
      Conserved Domains (4) summary
      cd06174
      Location:40 → 280
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:470 → 521
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:36 → 684
      OATP; Organic Anion Transporter Polypeptide (OATP) family
      pfam13273
      Location:364 → 447
      DUF4064; Protein of unknown function (DUF4064)

    2. NM_135724.4 → NP_609568.3  organic anion transporting polypeptide 33Ea, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609568.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK84
      Related
      FBpp0079966
      Conserved Domains (4) summary
      cd06174
      Location:40 → 280
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:470 → 521
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:36 → 684
      OATP; Organic Anion Transporter Polypeptide (OATP) family
      pfam13273
      Location:364 → 447
      DUF4064; Protein of unknown function (DUF4064)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SZ8 Q95SZ8
    Q9VK84 Q9VK84

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous