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    CG6454 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42904, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6454provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039187
    Locus tag
    Dmel_CG6454
    See related
    AllianceGenome:FB:FBgn0039187
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6454
    Summary
    Predicted to enable calcium ion binding activity and calcium-dependent phospholipid binding activity. Predicted to be involved in several processes, including intracellular protein transmembrane transport; positive regulation of protein targeting to membrane; and positive regulation of transport. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to human C2CD5 (C2 calcium dependent domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6454 in Genome Data Viewer
    Location:
    95F14-95F15; 3-84 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24349182..24356241)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20174904..20181963)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Myosuppressin Neighboring gene uncharacterized protein Neighboring gene Golgin-84 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and molecular analysis of the synaptotagmin family. Adolfsen B, et al. Cell Mol Life Sci, 2001 Mar. PMID 11315187, Free PMC Article
    2. Drosophila Insulin-Like Peptides DILP2 and DILP5 Differentially Stimulate Cell Signaling and Glycogen Phosphorylase to Regulate Longevity. Post S, et al. Front Endocrinol (Lausanne), 2018. PMID 29892262, Free PMC Article
    3. Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. Hansen KD, et al. PLoS Genet, 2009 Jun. PMID 19543372, Free PMC Article
    4. Chromosomal rearrangement inferred from comparisons of 12 Drosophila genomes. Bhutkar A, et al. Genetics, 2008 Jul. PMID 18622036, Free PMC Article
    5. Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Lowe N, et al. Development, 2014 Oct. PMID 25294943, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of D-glucose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6454-PC
    CG6454-PD
    CG6454-PE
    CG6454-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24349182..24356241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142992.3 → NP_651249.2  uncharacterized protein Dmel_CG6454, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651249.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMW9
      Conserved Domains (1) summary
      cd08688
      Location:5 → 121
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    2. NM_001414141.1 → NP_001401047.1  uncharacterized protein Dmel_CG6454, isoform F [Drosophila melanogaster]

      Status: REVIEWED

    3. NM_001275986.1 → NP_001262915.1  uncharacterized protein Dmel_CG6454, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262915.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGY2
      Conserved Domains (1) summary
      cd08688
      Location:5 → 121
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    4. NM_170141.3 → NP_732985.2  uncharacterized protein Dmel_CG6454, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732985.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VC89
      Conserved Domains (1) summary
      cd08688
      Location:5 → 121
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGY2 A0A0B4KGY2
    Q8IMW9 Q8IMW9
    Q8MR20 Q8MR20
    Q9VC89 Q9VC89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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