cas castor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: casprovided by FlyBase
Official Full Name: castorprovided by FlyBase
Primary source: FLYBASE:FBgn0004878
Locus tag: Dmel_CG2102
See related: AllianceGenome:FB:FBgn0004878
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Cas; CAS; CG2102; Dmel\CG2102; l(3)j1C2; l(3)neo33; ming
Summary: Enables DNA binding activity. Involved in several processes, including negative regulation of DNA-templated transcription; nervous system development; and regulation of neural precursor cell proliferation. Located in nucleus. Is expressed in several structures, including anterior-posterior subdivision of organism; central nervous system; glial cell; larval neurons; and somatic stem cell. Orthologous to human CASZ1 (castor zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 83C1-83C1; 3-47.5 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (5712975..5716805, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (1538697..1542527, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships.
Title: Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships.
The expression of castor protein is regulated by ABD-D protein in promoter region of castor gene.
Title: Sequence-specific interaction between ABD-B homeodomain and castor gene in Drosophila.
Castor (Cas) is a nuclear protein that is expressed in follicle stem cells and early follicle cell precursors and then is restricted to differentiated polar and stalk cells once egg chambers form
Title: Castor is required for Hedgehog-dependent cell-fate specification and follicle stem cell maintenance in Drosophila oogenesis.
a novel function for castor in regulating neuropeptide gene expression.
Title: Transcriptome analysis of Drosophila CNS midline cells reveals diverse peptidergic properties and a role for castor in neuronal differentiation.
Results suggest that the expression of cas is segment-specifically regulated negatively by Ubx and abdA genes, but positively by the AbdB gene.
Title: Drosophila castor is regulated negatively by the Ubx and abdA genes, but positively by the AbdB gene.
show that the products of the genes klumpfuss, nab and castor play important roles in their specification via a genetic cascade
Title: A genetic cascade involving klumpfuss, nab and castor specifies the abdominal leucokinergic neurons in the Drosophila CNS.
These results indicate that cas could be directly suppressed by Repo.
Title: Ectopic Repo suppresses expression of castor gene in Drosophila central nervous system.
These results provide a new neuroblast lineage for investigating temporal identity and reveal the importance of Pdm and Cas as timing factors that close temporal identity windows.
Title: Pdm and Castor close successive temporal identity windows in the NB3-1 lineage.
Pdm and Cas specify late-born neuronal identity; that Pdm and Cas act combinatorially to specify a temporal identity distinct from either protein alone, and that Cas repression of pdm expression regulates the generation of neuronal diversity.
Title: Pdm and Castor specify late-born motor neuron identity in the NB7-1 lineage.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ganglion mother cell fate determination	TAS Traceable Author Statement more info	PubMed
involved_in generation of neurons	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of development, heterochronic	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in ventral cord development	HMP more info	PubMed
involved_in ventral cord development	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed