Mcm7 Minichromosome maintenance 7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mcm7provided by FlyBase
Official Full Name: Minichromosome maintenance 7provided by FlyBase
Primary source: FLYBASE:FBgn0020633
Locus tag: Dmel_CG4978
See related: AllianceGenome:FB:FBgn0020633
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Liang-1.66; CG4978; clone 1.66; dMcm7; Dmel\CG4978; DmeMCM7; DmMCM7; mcm7; McM7; MCM7; Mcp-PCR1; PCR1
Summary: Contributes to 3'-5' DNA helicase activity. Predicted to be involved in DNA metabolic process. Part of CMG complex and MCM complex. Is expressed in several structures, including central brain primordium; embryonic dorsal epidermis; embryonic ventral epidermis; embryonic/larval midgut; and ganglia. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MCM7 (minichromosome maintenance complex component 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8891596..8894310)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8884696..8887410)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to 3'-5' DNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
contributes_to single-stranded DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication initiation	IEA Inferred from Electronic Annotation more info
involved_in DNA strand elongation involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA unwinding involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via break-induced replication	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of CMG complex	IDA Inferred from Direct Assay more info	PubMed
part_of MCM complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MCM complex	IDA Inferred from Direct Assay more info	PubMed
part_of MCM complex	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

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