U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    phu phurba tashi [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41135, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    phuprovided by FlyBase
    Official Full Name
    phurba tashiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0043791
    Locus tag
    Dmel_CG8147
    See related
    AllianceGenome:FB:FBgn0043791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    154821_at; Alp3; BEST:LD38109; CG8147; Dmel\CG8147
    Summary
    Predicted to enable alkaline phosphatase activity. Involved in response to hypoxia and response to nicotine. Predicted to be located in cell surface. Is expressed in several structures, including amnioserosa; embryonic/larval midgut primordium; endoderm anlage; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and inflammatory bowel disease. Orthologous to several human genes including ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See phu in Genome Data Viewer
    Location:
    85D18-85D18; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9494801..9496723)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5320523..5322445)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Glutathione S transferase Z2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45203 Neighboring gene Rho-like Neighboring gene uncharacterized protein Neighboring gene rumpelstiltskin

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Post-fasting olfactory, transcriptional, and feeding responses in Drosophila. Farhadian SF, et al. Physiol Behav, 2012 Jan 18. PMID 21945372, Free PMC Article
    2. Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster. Passador-Gurgel G, et al. Nat Genet, 2007 Feb. PMID 17237783
    3. Segmental duplication, microinversion, and gene loss associated with a complex inversion breakpoint region in Drosophila. Calvete O, et al. Mol Biol Evol, 2012 Jul. PMID 22328714, Free PMC Article
    4. Mitonuclear Interactions Mediate Transcriptional Responses to Hypoxia in Drosophila. Mossman JA, et al. Mol Biol Evol, 2017 Feb 1. PMID 28110272, Free PMC Article
    5. Wnt4 is required for ostia development in the Drosophila heart. Chen Z, et al. Dev Biol, 2016 May 15. PMID 26994311, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alkaline phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkaline phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to nicotine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    phurba tashi
    Names
    CG8147-PA
    alkaline phosphatase 3
    phu-PA
    NP_649897.4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9494801..9496723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141640.5 → NP_649897.4  phurba tashi [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649897.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3C7, Q9VHD0
      Conserved Domains (2) summary
      smart00098
      Location:93 → 530
      alkPPc; Alkaline phosphatase homologues
      COG1785
      Location:71 → 524
      PhoA; Alkaline phosphatase [Inorganic ion transport and metabolism, General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHD0 Q9VHD0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous