Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Celsr3provided by RGD
Official Full Name: cadherin, EGF LAG seven-pass G-type receptor 3provided by RGD
Primary source: RGD:621787
See related: EnsemblRapid:ENSRNOG00000053889 AllianceGenome:RGD:621787
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Megf2
Summary: Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Predicted to be involved in Wnt signaling pathway, planar cell polarity pathway; axon guidance; and cell-cell adhesion. Predicted to act upstream of or within several processes, including cilium assembly; generation of neurons; and regulation of protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Orthologous to human CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 37.7), Adrenal (RPKM 10.3) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (118409136..118438593)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (109530597..109558360)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (117620293..117648034)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Celsr3 suppressed neurite growth of neuron in hippocampus of rat.
Title: Opposing roles in neurite growth control by two seven-pass transmembrane cadherins.

Submit: New GeneRIF Correction

General gene information

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Markers

Celsr3 (e-PCR), detects polymorphism
- UniSTS:164879

BF406162 (e-PCR)
- UniSTS:248294

BF386320 (e-PCR)
- UniSTS:243688

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway, planar cell polarity pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axonal fasciculation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in dopaminergic neuron axon guidance	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within motor neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in serotonergic neuron axon guidance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cadherin EGF LAG seven-pass G-type receptor 3

Names: cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila); multiple EGF-like domains protein 2; multiple epidermal growth factor-like domains 2; multiple epidermal growth factor-like domains protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031320.1 → NP_112610.1 cadherin EGF LAG seven-pass G-type receptor 3 precursor

See identical proteins and their annotated locations for NP_112610.1

Status: PROVISIONAL

Source sequence(s)

AB011528

UniProtKB/Swiss-Prot

O88278

UniProtKB/TrEMBL

A0A8L2R1D5

Related

ENSRNOP00000068821.3, ENSRNOT00000084220.3

Conserved Domains (9) summary

smart00303
Location:2474 → 2527

GPS; G-protein-coupled receptor proteolytic site domain

cd11304
Location:646 → 743

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2117 → 2181

HormR; Domain present in hormone receptors

cd00054
Location:1717 → 1748

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:2067 → 2105

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1508 → 1691

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00002
Location:2534 → 2766

7tm_2; 7 transmembrane receptor (Secretin family)

pfam00053
Location:1994 → 2033

Laminin_EGF; Laminin EGF domain

pfam16489
Location:2201 → 2446

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

118409136..118438593

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243860.5 → XP_006243922.1 cadherin EGF LAG seven-pass G-type receptor 3 isoform X1

UniProtKB/TrEMBL

A0A8L2R1D5

Conserved Domains (9) summary

smart00303
Location:2474 → 2527

GPS; G-protein-coupled receptor proteolytic site domain

cd11304
Location:646 → 743

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2117 → 2181

HormR; Domain present in hormone receptors

cd00054
Location:1717 → 1748

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:2067 → 2105

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1508 → 1691

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00002
Location:2534 → 2765

7tm_2; 7 transmembrane receptor (Secretin family)

pfam00053
Location:1994 → 2033

Laminin_EGF; Laminin EGF domain

pfam16489
Location:2201 → 2446

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_039082204.2 → XP_038938132.1 cadherin EGF LAG seven-pass G-type receptor 3 isoform X2

UniProtKB/TrEMBL

A0A8L2R1D5

Conserved Domains (11) summary

smart00303
Location:2469 → 2522

GPS; G-protein-coupled receptor proteolytic site domain

cd11304
Location:646 → 743

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2117 → 2176

HormR; Domain present in hormone receptors

PHA03247
Location:3085 → 3284

PHA03247; large tegument protein UL36; Provisional

cd00054
Location:1717 → 1748

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:2067 → 2105

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1508 → 1691

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:1994 → 2033

Laminin_EGF; Laminin EGF domain

pfam16489
Location:2195 → 2443

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cd14964
Location:2531 → 2556

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:2529 → 2782

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039082205.2 → XP_038938133.1 cadherin EGF LAG seven-pass G-type receptor 3 isoform X3

UniProtKB/TrEMBL

A0A8L2R1D5

Conserved Domains (11) summary

smart00303
Location:2469 → 2522

GPS; G-protein-coupled receptor proteolytic site domain

cd11304
Location:646 → 743

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2117 → 2176

HormR; Domain present in hormone receptors

PHA03247
Location:3084 → 3283

PHA03247; large tegument protein UL36; Provisional

cd00054
Location:1717 → 1748

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:2067 → 2105

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1508 → 1691

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:1994 → 2033

Laminin_EGF; Laminin EGF domain

pfam16489
Location:2195 → 2443

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cd14964
Location:2531 → 2556

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:2529 → 2781

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_063266218.1 → XP_063122288.1 cadherin EGF LAG seven-pass G-type receptor 3 isoform X4
XM_006243861.5 → XP_006243923.1 cadherin EGF LAG seven-pass G-type receptor 3 isoform X5

UniProtKB/TrEMBL

A6I391

Conserved Domains (10) summary

smart00303
Location:2474 → 2527

GPS; G-protein-coupled receptor proteolytic site domain

cd11304
Location:646 → 743

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2117 → 2181

HormR; Domain present in hormone receptors

cd00054
Location:1717 → 1748

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:2067 → 2105

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1508 → 1691

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00002
Location:2534 → 2728

7tm_2; 7 transmembrane receptor (Secretin family)

pfam00053
Location:1994 → 2033

Laminin_EGF; Laminin EGF domain

pfam15576
Location:64 → 188

DUF4661; Domain of unknown function (DUF4661)

pfam16489
Location:2201 → 2446

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain