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    Dis3l DIS3 like exosome 3'-5' exoribonuclease [ Mus musculus (house mouse) ]

    Gene ID: 213550, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dis3lprovided by MGI
    Official Full Name
    DIS3 like exosome 3'-5' exoribonucleaseprovided by MGI
    Primary source
    MGI:MGI:2143272
    See related
    Ensembl:ENSMUSG00000032396 AllianceGenome:MGI:2143272
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable enzyme binding activity and exoribonuclease II activity. Predicted to be involved in RNA processing; mRNA catabolic process; and rRNA catabolic process. Predicted to be located in centrosome; cytosol; and plasma membrane. Predicted to be part of cytoplasmic exosome (RNase complex). Orthologous to human DIS3L (DIS3 like exosome 3'-5' exoribonuclease). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 24.6), cerebellum adult (RPKM 6.8) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dis3l in Genome Data Viewer
    Location:
    9 C; 9 34.62 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64214038..64248707, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64306756..64341403, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8856 Neighboring gene STARR-positive B cell enhancer ABC_E2293 Neighboring gene STARR-seq mESC enhancer starr_24425 Neighboring gene STARR-seq mESC enhancer starr_24427 Neighboring gene STARR-positive B cell enhancer ABC_E6754 Neighboring gene ubiquitin carboxyl-terminal esterase L4 Neighboring gene STARR-seq mESC enhancer starr_24428 Neighboring gene predicted gene, 24289 Neighboring gene timeless interacting protein Neighboring gene STARR-seq mESC enhancer starr_24432 Neighboring gene STARR-seq mESC enhancer starr_24433 Neighboring gene multiple EGF-like-domains 11 Neighboring gene STARR-seq mESC enhancer starr_24435 Neighboring gene STARR-positive B cell enhancer mm9_chr9:64519558-64519858 Neighboring gene STARR-positive B cell enhancer ABC_E9767 Neighboring gene predicted gene, 36311 Neighboring gene RAB11A, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of DIS3L in the initial segment is dispensable for sperm maturation in the epididymis and male fertility. Wang X, et al. Reprod Biol, 2024 Sep. PMID 38875746
    2. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. Tomecki R, et al. EMBO J, 2010 Jul 21. PMID 20531386, Free PMC Article
    3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of DIS3L in the initial segment is dispensable for sperm maturation in the epididymis and male fertility.
      Title: Loss of DIS3L in the initial segment is dispensable for sperm maturation in the epididymis and male fertility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5'-RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3'-5'-RNA exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables exoribonuclease II activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables exoribonuclease II activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DIS3-like exonuclease 1
    Names
    DIS3 mitotic control homolog-like
    NP_001001295.2
    NP_001171255.1
    NP_766107.1
    XP_006511045.1
    XP_011241002.1
    XP_030100066.1
    XP_036010677.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001295.2 → NP_001001295.2  DIS3-like exonuclease 1 isoform 1

      See identical proteins and their annotated locations for NP_001001295.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC056939, BM900123, BY497083, CJ157436
      Consensus CDS
      CCDS52832.1
      UniProtKB/Swiss-Prot
      Q69Z56, Q8C0S1
      Related
      ENSMUSP00000129772.3, ENSMUST00000168844.9
      Conserved Domains (3) summary
      COG0557
      Location:265 → 899
      VacB; Exoribonuclease R [Transcription]
      cd09862
      Location:11 → 188
      PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
      pfam17215
      Location:875 → 958
      Rrp44_S1; S1 domain

    2. NM_001177784.1 → NP_001171255.1  DIS3-like exonuclease 1 isoform 2

      See identical proteins and their annotated locations for NP_001171255.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC135358, AK077031, BM900123, BY497083
      Consensus CDS
      CCDS23280.1
      UniProtKB/Swiss-Prot
      Q8C0S1
      Related
      ENSMUSP00000113503.2, ENSMUST00000120760.8
      Conserved Domains (3) summary
      COG0557
      Location:182 → 816
      VacB; Exoribonuclease R [Transcription]
      pfam17215
      Location:792 → 875
      Rrp44_S1; S1 domain
      cl28905
      Location:1 → 105
      PIN_SF; PIN (PilT N terminus) domain: Superfamily

    3. NM_172519.3 → NP_766107.1  DIS3-like exonuclease 1 isoform 2

      See identical proteins and their annotated locations for NP_766107.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK029974, BM900123, BY497083
      Consensus CDS
      CCDS23280.1
      UniProtKB/Swiss-Prot
      Q8C0S1
      Related
      ENSMUSP00000109522.2, ENSMUST00000113890.2
      Conserved Domains (3) summary
      COG0557
      Location:182 → 816
      VacB; Exoribonuclease R [Transcription]
      pfam17215
      Location:792 → 875
      Rrp44_S1; S1 domain
      cl28905
      Location:1 → 105
      PIN_SF; PIN (PilT N terminus) domain: Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      64214038..64248707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244206.2 → XP_030100066.1  DIS3-like exonuclease 1 isoform X1

      Conserved Domains (3) summary
      COG0557
      Location:131 → 765
      VacB; Exoribonuclease R [Transcription]
      pfam17215
      Location:741 → 824
      Rrp44_S1; S1 domain
      cl28905
      Location:1 → 54
      PIN_SF; PIN (PilT N terminus) domain: Superfamily

    2. XM_011242700.3 → XP_011241002.1  DIS3-like exonuclease 1 isoform X1

      See identical proteins and their annotated locations for XP_011241002.1

      Conserved Domains (3) summary
      COG0557
      Location:131 → 765
      VacB; Exoribonuclease R [Transcription]
      pfam17215
      Location:741 → 824
      Rrp44_S1; S1 domain
      cl28905
      Location:1 → 54
      PIN_SF; PIN (PilT N terminus) domain: Superfamily

    3. XM_036154784.1 → XP_036010677.1  DIS3-like exonuclease 1 isoform X3

      Conserved Domains (2) summary
      COG0557
      Location:33 → 602
      VacB; Exoribonuclease R [Transcription]
      pfam17215
      Location:578 → 661
      Rrp44_S1; S1 domain

    4. XM_006510982.5 → XP_006511045.1  DIS3-like exonuclease 1 isoform X2

      See identical proteins and their annotated locations for XP_006511045.1

      UniProtKB/Swiss-Prot
      Q8C0S1
      Conserved Domains (3) summary
      COG0557
      Location:182 → 816
      VacB; Exoribonuclease R [Transcription]
      pfam17215
      Location:792 → 875
      Rrp44_S1; S1 domain
      cl28905
      Location:1 → 105
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0S1.2 GenPept UniProtKB/Swiss-Prot:Q8C0S1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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