Adrb1 adrenoceptor beta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adrb1provided by RGD
Official Full Name: adrenoceptor beta 1provided by RGD
Primary source: RGD:2059
See related: EnsemblRapid:ENSRNOG00000017002 AllianceGenome:RGD:2059
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: B1AR; RATB1AR
Summary: Enables amine binding activity and beta1-adrenergic receptor activity. Involved in several processes, including positive regulation of cation transmembrane transport; regulation of heart contraction; and regulation of muscle system process. Located in plasma membrane. Used to study congestive heart failure; dilated cardiomyopathy; myocardial infarction; periodontitis; and renovascular hypertension. Biomarker of hyperglycemia; hypertension; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Orthologous to human ADRB1 (adrenoceptor beta 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (265777103..265780114)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (255771962..255774973)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (277537585..277538985)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta1-adrenergic receptor but not beta2 mediates osteogenic differentiation of bone marrow mesenchymal stem cells in normotensive and hypertensive rats.
Title: β1-adrenergic receptor but not β2 mediates osteogenic differentiation of bone marrow mesenchymal stem cells in normotensive and hypertensive rats.
Sympathetic Stimulation Upregulates the Ca(2+) Channel Subunit, CaValpha2delta1, via the beta1 and ERK 1/2 Pathway in Neonatal Ventricular Cardiomyocytes.
Title: Sympathetic Stimulation Upregulates the Ca(2+) Channel Subunit, Ca(V)α2δ1, via the β1 and ERK 1/2 Pathway in Neonatal Ventricular Cardiomyocytes.
O-GlcNAc transferase affects the signal transduction of beta1 adrenoceptor in adult rat cardiomyocytes by increasing the O-GlcNAcylation of beta1 adrenoceptor.
Title: O-GlcNAc transferase affects the signal transduction of β1 adrenoceptor in adult rat cardiomyocytes by increasing the O-GlcNAcylation of β1 adrenoceptor.
Data show that beta 2 adrenergic receptors (beta2AR) Activation compartmentalizes beta-1 adrenergic receptor (beta1AR) signaling.
Title: β(2)-Adrenergic Stimulation Compartmentalizes β(1) Signaling Into Nanoscale Local Domains by Targeting the C-Terminus of β(1)-Adrenoceptors.
The authors demonstrate that endogenous beta1-adrenergic receptors at the Golgi apparatus in cardiac myocytes are required to stimulate hypertrophic Epac/PLCe-dependent phosphatidylinositol 4-phosphate hydrolysis at the Golgi, and that these intracellular beta1-adrenergic receptors can be accessed by physiological neurotransmitters, and synthetic b-blockers and agonists.
Title: Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy.
These results showed that prolonged action of adrenoceptor beta 1- autoantibodys significantly reduced the autophagy of myocardial tissues and H9c2 cardiomyocytes, and endoplasmic reticulum stress and its related apoptotic pathways were significantly activated.
Title: Endoplasmic reticulum stress contributed to β1-adrenoceptor autoantibody-induced reduction of autophagy in cardiomyocytes.
Cerebral embolization impaired the myocardial expression of ADRB1.
Title: Ischemic Stroke Increases Heart Vulnerability to Ischemia-Reperfusion and Alters Myocardial Cardioprotective Pathways.
Despite enhanced agonist-mediated downregulation of hepatic beta-ARs preferentially affecting the beta2-AR subtype, increased generation of both receptor subtypes during aging augments the pool of plasma membrane-bound beta-ARs coupled to adenylyl cyclase in hepatocytes.
Title: Altered expression of hepatic β-adrenergic receptors in aging rats: implications for age-related metabolic dysfunction in liver.
lower b1-adrenoreceptor expression was significantly associated with increased lymph node metastasis. Reduced b2-adrenoreceptor staining proportion was significantly associated with worse histological grade. Furthermore, the proportion of b2-adrenoreceptor staining was significantly lower in tumors with diffuse-type histology, than those with intestinal-type histology.
Title: Lower Sympathetic Nervous System Density and β-adrenoreceptor Expression Are Involved in Gastric Cancer Progression.
beta-AR stimulation affects post-translational modifications of NF2 via the involvement beta1-AR/PKA/cAMP pathway, and NF2 plays a pro-apoptotic role in beta-AR-stimulated myocyte apoptosis via the phosphorylation (inactivation) of YAP and involvement of mitochondrial death pathway
Title: NF2 signaling pathway plays a pro-apoptotic role in β-adrenergic receptor stimulated cardiac myocyte apoptosis.

Submit: New GeneRIF Correction See all GeneRIFs (95)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Arb28 (e-PCR)
- UniSTS:240134

D1Smu1 (e-PCR)
- UniSTS:517780

Adrb1 (e-PCR), detects polymorphism
- UniSTS:256461

UniSTS:141043 (e-PCR)
- UniSTS:141043

Adrb1 (e-PCR), detects polymorphism
- UniSTS:141043

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables alpha-2A adrenergic receptor binding	IEA Inferred from Electronic Annotation more info
enables alpha-2A adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables amine binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta1-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta1-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables beta1-adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables beta1-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables beta1-adrenergic receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in diet induced thermogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within diet induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in fear response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fear response	ISO Inferred from Sequence Orthology more info
involved_in glycogen catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heat generation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heat generation	ISO Inferred from Sequence Orthology more info
involved_in inhibitory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of urine volume	IDA Inferred from Direct Assay more info	PubMed
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of adenylate cyclase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cation channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heart rate by epinephrine-norepinephrine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of heart rate by epinephrine-norepinephrine	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of the force of heart contraction by epinephrine-norepinephrine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of the force of heart contraction by epinephrine-norepinephrine	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of the force of heart contraction by norepinephrine	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to organelle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cardiac muscle cell contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cardiac muscle cell contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle, sleep	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian sleep/wake cycle, sleep	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian sleep/wake cycle, sleep	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in response to cold	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cold	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal dense core vesicle	IEA Inferred from Electronic Annotation more info
is_active_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-1 adrenergic receptor

Names: adrenergic receptor, beta 1; adrenergic, beta-1-, receptor; beta 1-adrenergic receptor beta 1-AR; beta-1 adrenoceptor; beta-1 adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.