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    Fas Fas cell surface death receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246097, updated on 27-Nov-2024

    Summary

    Official Symbol
    Fasprovided by RGD
    Official Full Name
    Fas cell surface death receptorprovided by RGD
    Primary source
    RGD:619831
    See related
    EnsemblRapid:ENSRNOG00000019142 AllianceGenome:RGD:619831
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    FasR; Tnfrsf6
    Summary
    Enables protease binding activity; protein phosphatase binding activity; and tumor necrosis factor receptor activity. Involved in several processes, including cellular response to cobalt ion; cellular response to cytokine stimulus; and nervous system development. Located in several cellular components, including apical dendrite; external side of plasma membrane; and sarcolemma. Part of CD95 death-inducing signaling complex. Used to study IgA glomerulonephritis; brain glioma; pre-malignant neoplasm; retinal detachment; and transient cerebral ischemia. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; artery disease (multiple); brain ischemia (multiple); eye disease (multiple); and liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 328.9), Lung (RPKM 56.6) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fas in Genome Data Viewer
    Location:
    1q52
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (241212155..241245774)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (231798963..231832591)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (252589785..252624790)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene actin alpha 2, smooth muscle Neighboring gene death effector domain-containing, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134485223 Neighboring gene cholesterol 25-hydroxylase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables tumor necrosis factor receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tumor necrosis factor receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables tumor necrosis factor receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Fas signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within T cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation-induced cell death of T cells IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within activation-induced cell death of T cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cobalt ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to cytokine stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to estrogen stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to hydrostatic pressure IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to hyperoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to lithium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to phenylalanine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to type II interferon IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chordate embryonic development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendrite regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hepatocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inflammatory cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within lymphocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maternal process involved in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in motor neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within motor neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in necroptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within necroptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in necroptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of B cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of Schwann cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Schwann cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative thymic T cell selection ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ovarian follicle atresia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in ovulation cycle IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of lipid storage IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of stress-activated MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cycloheximide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to cytokine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to fluoride IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to growth factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ischemia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within spleen development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telencephalon development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of CD95 death-inducing signaling complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CD95 death-inducing signaling complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of CD95 death-inducing signaling complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of death-inducing signaling complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of death-inducing signaling complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tumor necrosis factor receptor superfamily member 6
    Names
    CD95 antigen
    FASLG receptor
    Fas (TNF receptor superfamily, member 6)
    Fas antigen (ATP1)
    Fas receptor
    Tumor necrosis factor receptor superfamily, member 6
    apo-1 antigen
    apoptosis-mediating surface antigen FAS

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139194.3NP_631933.2  tumor necrosis factor receptor superfamily member 6 precursor

      See identical proteins and their annotated locations for NP_631933.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q63199
      UniProtKB/TrEMBL
      A6I127, F1LWQ2
      Related
      ENSRNOP00000025928.4, ENSRNOT00000025928.7
      Conserved Domains (2) summary
      cd08316
      Location:215308
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd10579
      Location:35164
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      241212155..241245774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)