U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Pdgfb platelet derived growth factor, B polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 18591, updated on 14-Jan-2025

    Summary

    Official Symbol
    Pdgfbprovided by MGI
    Official Full Name
    platelet derived growth factor, B polypeptideprovided by MGI
    Primary source
    MGI:MGI:97528
    See related
    Ensembl:ENSMUSG00000000489 AllianceGenome:MGI:97528
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sis; c-sis; PDGF-2; PDGF-B
    Summary
    Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; metanephric glomerulus vasculature development; and paracrine signaling. Acts upstream of or within several processes, including nervous system development; salivary gland morphogenesis; and vasculature development. Predicted to be located in several cellular components, including basolateral plasma membrane; cell surface; and neuronal cell body. Predicted to be part of platelet-derived growth factor complex. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; female reproductive system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including basal ganglia calcification; clear cell renal cell carcinoma; dermatofibrosarcoma protuberans; familial meningioma; and high grade glioma (multiple). Orthologous to human PDGFB (platelet derived growth factor subunit B). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in lung adult (RPKM 24.0), adrenal adult (RPKM 10.1) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pdgfb in Genome Data Viewer
    Location:
    15 E1; 15 37.85 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79880066..79899178, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79995865..80024614, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 Neighboring gene STARR-seq mESC enhancer starr_39204 Neighboring gene STARR-positive B cell enhancer ABC_E7392 Neighboring gene chromobox 7 Neighboring gene STARR-positive B cell enhancer mm9_chr15:79765174-79765475 Neighboring gene STARR-positive B cell enhancer ABC_E9420 Neighboring gene VISTA enhancer mm570 Neighboring gene STARR-seq mESC enhancer starr_39213 Neighboring gene predicted gene, 53903 Neighboring gene microRNA 7213 Neighboring gene predicted gene, 41361 Neighboring gene predicted gene, 53904 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:79880582-79880810 Neighboring gene predicted gene, 41362

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chemoattractant activity  
    enables collagen binding  
    enables growth factor activity  
    enables growth factor activity  
    enables identical protein binding  
    enables platelet-derived growth factor binding  
    enables platelet-derived growth factor receptor binding  
    enables platelet-derived growth factor receptor binding  
    enables platelet-derived growth factor receptor binding  
    enables protein heterodimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables signaling receptor binding  
    enables superoxide-generating NADPH oxidase activator activity  
    enables superoxide-generating NADPH oxidase activator activity  
    Items 1 - 25 of 134
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization PubMed 
    acts_upstream_of_or_within actin cytoskeleton organization PubMed 
    involved_in angiogenesis  
    involved_in blood vessel development PubMed 
    acts_upstream_of_or_within blood vessel morphogenesis PubMed 
    acts_upstream_of_or_within blood vessel morphogenesis PubMed 
    acts_upstream_of_or_within branching involved in salivary gland morphogenesis PubMed 
    involved_in cardiac vascular smooth muscle cell differentiation PubMed 
    involved_in cell chemotaxis  
    involved_in cell chemotaxis  
    acts_upstream_of cell migration PubMed 
    acts_upstream_of_or_within cell projection assembly PubMed 
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to mycophenolic acid  
    involved_in cellular response to mycophenolic acid  
    involved_in cellular response to platelet-derived growth factor stimulus PubMed 
    involved_in embryonic placenta development PubMed 
    acts_upstream_of endothelial cell proliferation PubMed 
    acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis PubMed 
    acts_upstream_of_or_within eye photoreceptor cell development PubMed 
    acts_upstream_of fibroblast growth factor receptor signaling pathway PubMed 
    acts_upstream_of_or_within fibroblast migration PubMed 
    acts_upstream_of fibroblast migration PubMed 
    involved_in gene expression  
    acts_upstream_of_or_within glial cell development PubMed 
    involved_in heart development PubMed 
    NOT involved_in hemopoiesis  
    involved_in interleukin-18-mediated signaling pathway  
    involved_in metanephric glomerular endothelium development PubMed 
    involved_in metanephric glomerular mesangial cell development PubMed 
    involved_in metanephric glomerular mesangial cell proliferation involved in metanephros development PubMed 
    involved_in monocyte chemotaxis  
    involved_in monocyte chemotaxis  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of miRNA transcription  
    involved_in negative regulation of phosphatidylinositol biosynthetic process  
    involved_in negative regulation of phosphatidylinositol biosynthetic process  
    involved_in negative regulation of platelet activation  
    involved_in negative regulation of platelet activation  
    involved_in negative regulation of protein binding  
    involved_in negative regulation of vascular associated smooth muscle cell differentiation  
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration PubMed 
    acts_upstream_of_or_within neuron remodeling PubMed 
    involved_in paracrine signaling PubMed 
    involved_in peptidyl-tyrosine phosphorylation  
    involved_in peptidyl-tyrosine phosphorylation  
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in platelet-derived growth factor receptor signaling pathway  
    involved_in platelet-derived growth factor receptor signaling pathway  
    involved_in platelet-derived growth factor receptor signaling pathway  
    involved_in platelet-derived growth factor receptor signaling pathway PubMed 
    involved_in positive regulation of DNA biosynthetic process  
    involved_in positive regulation of DNA biosynthetic process  
    involved_in positive regulation of DNA replication  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of MAP kinase activity  
    involved_in positive regulation of MAP kinase activity  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of blood vessel endothelial cell migration  
    involved_in positive regulation of blood vessel endothelial cell migration  
    involved_in positive regulation of calcium ion import  
    involved_in positive regulation of calcium ion import  
    involved_in positive regulation of cell division  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell-substrate adhesion  
    involved_in positive regulation of chemotaxis  
    involved_in positive regulation of chemotaxis  
    involved_in positive regulation of collagen biosynthetic process  
    acts_upstream_of_or_within positive regulation of endothelial cell proliferation PubMed 
    involved_in positive regulation of endothelial cell proliferation  
    acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway PubMed 
    acts_upstream_of_or_within positive regulation of fibroblast migration PubMed 
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of glomerular filtration PubMed 
    involved_in positive regulation of glomerular mesangial cell proliferation  
    involved_in positive regulation of glomerular mesangial cell proliferation  
    involved_in positive regulation of hepatic stellate cell activation  
    involved_in positive regulation of hepatic stellate cell proliferation  
    involved_in positive regulation of hyaluronan biosynthetic process  
    involved_in positive regulation of hyaluronan biosynthetic process  
    involved_in positive regulation of metanephric mesenchymal cell migration  
    involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of miRNA transcription  
    acts_upstream_of_or_within positive regulation of mitotic cell cycle, embryonic PubMed 
    involved_in positive regulation of mitotic nuclear division  
    involved_in positive regulation of mitotic nuclear division  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of protein autophosphorylation  
    involved_in positive regulation of protein autophosphorylation  
    involved_in positive regulation of reactive oxygen species metabolic process  
    involved_in positive regulation of reactive oxygen species metabolic process  
    involved_in positive regulation of smooth muscle cell migration PubMed 
    involved_in positive regulation of smooth muscle cell migration  
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of vascular associated smooth muscle cell dedifferentiation  
    involved_in positive regulation of vascular associated smooth muscle cell migration  
    acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell proliferation PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation  
    involved_in positive regulation of vasoconstriction PubMed 
    involved_in protein kinase C signaling  
    involved_in protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in reactive oxygen species metabolic process  
    involved_in reactive oxygen species metabolic process  
    acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in response to wounding  
    involved_in response to wounding  
    acts_upstream_of_or_within retina development in camera-type eye PubMed 
    acts_upstream_of_or_within retina vasculature development in camera-type eye PubMed 
    acts_upstream_of_or_within substrate-dependent cell migration PubMed 
    acts_upstream_of_or_within synapse assembly PubMed 
    acts_upstream_of vascular associated smooth muscle cell migration PubMed 
    acts_upstream_of vascular associated smooth muscle cell proliferation PubMed 
    involved_in vasoconstriction PubMed 
    Items 1 - 25 of 134
    Component Evidence Code Pubs
    located_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    located_in cell surface  
    located_in cell surface  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in dendrite  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in neuronal cell body  
    part_of platelet-derived growth factor complex  

    General protein information

    Preferred Names
    platelet-derived growth factor subunit B
    Names
    PDGF subunit B
    platelet-derived growth factor B chain
    platelet-derived growth factor beta polypeptide
    proto-oncogene c-Sis

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411619.1NP_001398548.1  platelet-derived growth factor subunit B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113595
      UniProtKB/TrEMBL
      Q8R3X9
    2. NM_001411620.1NP_001398549.1  platelet-derived growth factor subunit B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113595
      UniProtKB/TrEMBL
      Q8R3X9
      Related
      ENSMUSP00000155133.2, ENSMUST00000229912.2
    3. NM_011057.5NP_035187.2  platelet-derived growth factor subunit B isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_035187.2

      Status: VALIDATED

      Source sequence(s)
      AC113595
      Consensus CDS
      CCDS27656.1
      UniProtKB/Swiss-Prot
      P31240, Q6P3C4
      UniProtKB/TrEMBL
      A0A0R4IZW4, Q549C6
      Related
      ENSMUSP00000000500.7, ENSMUST00000000500.8
      Conserved Domains (2) summary
      pfam00341
      Location:97180
      PDGF; PDGF/VEGF domain
      pfam04692
      Location:2193
      PDGF_N; Platelet-derived growth factor, N terminal region

    RNA

    1. NR_177435.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113595
    2. NR_177436.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113595
    3. NR_177437.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113595

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79880066..79899178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520592.5XP_006520655.1  platelet-derived growth factor subunit B isoform X2

      UniProtKB/TrEMBL
      Q8R3X9
      Conserved Domains (1) summary
      pfam00341
      Location:34117
      PDGF; PDGF/VEGF domain
    External link. Please review our privacy policy.