Cnn1 calponin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cnn1provided by RGD
Official Full Name: calponin 1provided by RGD
Primary source: RGD:621883
See related: EnsemblRapid:ENSRNOG00000027736 AllianceGenome:RGD:621883
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables actin binding activity. Predicted to be involved in actin filament organization and negative regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in cytoskeleton. Predicted to be active in actin cytoskeleton. Orthologous to human CNN1 (calponin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 949.4), Lung (RPKM 173.3) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (28908437..28917099)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (20632434..20641097)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (23113083..23121748)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oxidative stress may contribute to the increase in aortic MMP-2 activity, possibly by S-glutathiolation, and this may result in calponin-1 loss and maladaptive vascular remodeling in early hypertension.
Title: Matrix metalloproteinase (MMP)-2 activation by oxidative stress decreases aortic calponin-1 levels during hypertrophic remodeling in early hypertension.
MMP-2 activity is increased in both conductance and resistance arteries in hypertension and contributes to early vascular dysfunction and remodelling. These maladaptive effects were related to the divergent regulation of calponin-1, which is decreased in aortas while is increased in resistance arteries.
Title: Matrix Metalloproteinase-2 Activity is Associated with Divergent Regulation of Calponin-1 in Conductance and Resistance Arteries in Hypertension-induced Early Vascular Dysfunction and Remodelling.
Actin cytoskeleton depolymerization inhibites BMP2 signaling via blocking of Smad by dephosphorylated CNN1 in osteoblast cells under simulated microgravity.
Title: Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in preosteoblast under simulated microgravity.
Data suggest that proteolysis of calponin-1 by Mmp2 (matrix metallopeptidase 2) contributes to the down-regulation of calponin-1 in cytoplasm of endothelium and smooth muscle of aorta/arteries in early (1-week) hypertension; however, at 2-weeks, calponin-1 is up-regulated.
Title: Matrix metalloproteinase (MMP)-2 decreases calponin-1 levels and contributes to arterial remodeling in early hypertension.
Calponin 1 is present in the cervix of virgin, 11 day, and 20 day pregnant rats.
Title: The persistence of active smooth muscle in the female rat cervix through pregnancy.
Data indicte that desmin and h1-calponin are expressed in mesenchymal stem cells (MSC).
Title: Differentiated markers in undifferentiated cells: expression of smooth muscle contractile proteins in multipotent bone marrow mesenchymal stem cells.
Calcitonin gene-related peptide significantly upregulated Cnn1 and downregulated OPN in corpus cavernosum smooth muscle cells from diabetic rats with erectile dysfunction.
Title: [Calcitonin gene-related peptide induces phenotypic transformation of corpus cavernosum smooth muscle cells in diabetic rats with erectile dysfunction].
Calponin-1 is a target of MMP-2, which contributes to endotoxemia-induced vascular hypocontractility.
Title: Matrix metalloproteinase-2 proteolysis of calponin-1 contributes to vascular hypocontractility in endotoxemic rats.
comparison between the basic C-terminal half of rat nonmuscle CALD1 and calponin, another actin-binding protein that is also basic and has similar actin-regulatory activities
Title: Role of the basic C-terminal half of caldesmon in its regulation of F-actin: comparison between caldesmon and calponin.
the frequency-dependent expression of h1-calponin under cyclic strain is mediated at least partly by the regulation of Rac and Rho-GDI alpha expression on the activation of p38 pathway
Title: Role of Rac and Rho-GDI alpha in the frequency-dependent expression of h1-calponin in vascular smooth muscle cells under cyclic mechanical strain.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin structure organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calponin-1

Names: basic calponin; calponin 1, basic, smooth muscle; calponin 1, smooth muscle; calponin H1, smooth muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031747.2 → NP_113935.2 calponin-1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q08290

UniProtKB/TrEMBL

A0A8L2QH34, A6JNY4

Related

ENSRNOP00000029782.7, ENSRNOT00000029577.8

Conserved Domains (2) summary

pfam00402
Location:164 → 188

Calponin; Calponin family repeat

cd21282
Location:27 → 134

CH_CNN1; calponin homology (CH) domain found in calponin-1 and similar proteins